...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Genes, brain, and behavior >Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice
【24h】

Persistent conditioned place preference to aggression experience in adult male sexually-experienced CD-1 mice

机译：持续条件的偏好于成年男性性爱经验的CD-1小鼠侵略经验

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We recently developed a conditioned place preference (CPP) procedure, commonly used to study rewarding drug effects, to demonstrate that dominant sexually-experienced CD-1 male mice form CPP to contexts previously associated with defeating subordinate male C57BL/6J mice. Here we further characterized conditioned and unconditioned aggression behavior in CD-1 mice. In Exp. 1 we used CD-1 mice that displayed a variable spectrum of unconditioned aggressive behavior toward younger subordinate C57BL/6J intruder mice. We then trained the CD-1 mice in the CPP procedure where one context was intruder-paired, while a different context was not. We then tested for aggression CPP 1 day after training. In Exp. 2, we tested CD-1 mice for aggression CPP 1 day and 18 days after training. In Exp. 3-4, we trained the CD-1 mice to lever-press for palatable food and tested them for footshock punishment-induced suppression of food-reinforced responding. In Exp. 5, we characterized unconditioned aggression in hybrid CD-1 x C57BL/6J D1-Cre or D2-Cre F1 generation crosses. Persistent aggression CPP was observed in CD-1 mice that either immediately attacked C57BL/6J mice during all screening sessions or mice that gradually developed aggressive behavior during the screening phase. In contrast, CD-1 mice that did not attack the C57BL/6J mice during screening did not develop CPP to contexts previously paired with C57BL/6J mice. The aggressive phenotype did not predict resistance to punishment-induced suppression of food-reinforced responding. CD-1 x D1-Cre or D2-Cre F1 transgenic mice showed strong unconditioned aggression. Our study demonstrates that aggression experience causes persistent CPP and introduces transgenic mice for circuit studies of aggression.
机译：我们最近开发了一个有条件的地方偏好（CPP）程序，通常用于研究奖励药物影响，证明显性性有效的CD-1雄性小鼠在先前与击败下属雄性C57BL / 6J小鼠相关联的上下文中形成CPP。在这里，我们进一步表征了CD-1小鼠的条件和无条件的侵略性行为。在exp。 1我们使用CD-1小鼠，为年轻从属C57BL / 6J入侵小鼠展示了无条件的无条件攻击行为的可变频谱。然后，我们在CPP程序中培训了CD-1小鼠，其中一个上下文是对的，而不同的背景不是。然后我们在训练后1天测试了攻击CPP。在exp。 2，我们在训练后1天和18天测试了CD-1小鼠的攻击CPP。在exp。 3-4，我们培训了CD-1小鼠以适应可口的食物，并测试它们用于徒刑造成的食物增强响应的抑制。在exp。 5，我们在混合CD-1 x C57BL / 6JD1-CRE或D2-CRE F1生成交叉中表征无条件的侵略。在CD-1小鼠中观察到持续性侵略性CPP，在所有筛选会话或小鼠中立即攻击C57BL / 6J小鼠，在筛选阶段逐渐发展侵略性行为。相反，在筛选期间没有攻击C57BL / 6J小鼠的CD-1小鼠并未将CPP与先前与C57BL / 6J小鼠配对的上下文。侵略性表型并未预测抗惩罚诱导的食物增强响应的抑制。 CD-1 X D1-CRE或D2-CRE F1转基因小鼠显示出强烈的无条件侵略。我们的研究表明，侵略经验导致持续的CPP并引入转基因小鼠进行电路研究的侵略性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号