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首页> 外文期刊>Geoderma: An International Journal of Soil Science >Immunohistochemical Expression of MCAM/CD146 in Canine Melanoma
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Immunohistochemical Expression of MCAM/CD146 in Canine Melanoma

机译：MCAM / CD146在犬黑色瘤中的免疫组织化学表达

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摘要

MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and promotes tumour growth, angiogenesis and metastasis. Melanoma is the most common malignant oral tumour of dogs and also arises in the skin, nail bed and footpad. The aim of this study was to investigate the immunohistochemical expression of MCAM/CD146 in 51 canine melanomas, including oral, cutaneous and ocular tumours. Seventeen of the 51 (33.3%) cases were negative, eight (15.7%) were weakly positive, seven (13.7%) were moderately positive and 19 (37.3%) were strongly positive. MCAM/CD146 was expressed by both oral and cutaneous melanomas; however, the intensity and the extent of the immunoreactivity was higher in oral (P = 0.009) than in cutaneous tumours (P = 0.058). Most ocular melanomas did not express MCAM/CD146 (P = 0.256). Expression of MCAM/CD146 by canine melanomas may suggest the molecule as a target for treatment, especially in oral melanomas.
机译：MCAM / CD146（黑色素瘤细胞粘附分子/ CD146）是跨越常态迁移和信号转导的跨膜免疫球蛋白超家族细胞粘附分子。它表达了黑色素瘤，鳞状细胞癌，前列腺，卵巢，宫颈癌和子宫内膜癌症，促进肿瘤生长，血管生成和转移。黑色素瘤是最常见的狗恶性口服肿瘤，也是在皮肤，指甲床和脚板上出现。本研究的目的是研究MCAM / CD146在51个犬黑色素瘤中的免疫组织化学表达，包括口服，皮肤和眼部肿瘤。 51（33.3％）病例的17例为阴性，八（15.7％）弱阳性，7（13.7％）适度阳性，19（37.3％）强烈阳性。 MCAM / CD146由口腔和皮肤黑色素组表达;然而，口腔（P = 0.009）的强度和免疫反应程度高于皮肤肿瘤（P = 0.058）。大多数眼黑色素瘤不表达MCAM / CD146（P = 0.256）。 Canine Melanomas的MCAM / CD146的表达可以提示分子作为治疗的靶标，特别是在口服黑色素瘤中。

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