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首页> 外文期刊>Genomics >Neofunctionalization of the UCP1 mediated the non-shivering thermogenesis in the evolution of small-sized placental mammals
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Neofunctionalization of the UCP1 mediated the non-shivering thermogenesis in the evolution of small-sized placental mammals

机译：UCP1的新官能化介导在小尺寸胎盘哺乳动物的演变中介导非颤抖的热生成

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摘要

The acquisition of UCP1-mediated non-shivering thermogenesis (NST) was an important event during the evolution of mammals. Here, we assessed the thermogenic neofunctionalization that occurred in the mammalian UCP1, by performing detailed comparative evolutionary genomics analyses (including phylogenetic and selection analyses) of the UCP family members across all major vertebrate classes. Heterogeneously distributed positive selection signatures were found in several UCPs, being preferably located in the mitochondrial matrix domains. Additionally, comparisons with non-mammalian orthologs showed increased evolutionary rates of the mammalian UCP1, not observable in the phylogenetically related UCP2 and UCP3 paralogs. Also, parallel signatures of episodic positive selection (omega > 1) were found in the ancestral branches of both Glires (rodents and lagomorphs) and Afroinsectivores (afrosoricids and macroscelids), underlining the importance of the UCP1 thermogenic activity in these mammalian groups. Finally, we hypothesize that the independent positive selection events that occurred in these two lineages resulted in two UCP1-mediated NST approaches, namely the cold acute response in the Glires and the reproduction success enhancement in the Afroinsectivores.
机译：采集UCP1介导的非颤动的热生成（NST）是哺乳动物演变过程中的重要事件。在此，我们通过在所有主要脊椎动物类别中进行UCP家族成员的详细的比较进化基因组学分析（包括系统和选择分析），评估了在哺乳动物UCP1中发生的热官能化。在几个UCP中发现异质分布的阳性选择签名，优选位于线粒体基质结构域中。另外，具有非哺乳动物的比较表明哺乳动物UCP1的进化率增加，在系统源相关的UCP2和UCP3常规蛋白酶中不可观察到。此外，在Glires（啮齿动物和Lagomorphs）的祖先分支和非洲蛋白结肠（Afrooricids和Macroscelid）的祖先分支中发现了焦化阳性选择（Omega> 1）的并行签名，强调了这些哺乳动物组UCP1热活性的重要性。最后，我们假设这两个谱系发生的独立阳性选择事件导致两种UCP1介导的NST方法，即GLIRE中的冷急性反应以及非洲宫内节病程中的再生成功增强。

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