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The regulatory functions of circular RNAs in osteosarcoma

机译：骨肉瘤圆形RNA的调节功能

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摘要

Osteosarcoma (OS) is known as a malignant bone tumor affecting mainly children and younger adults. Despite all the improvements in the treatment of OS, the overall survival among patients remained mostly unsatisfied. It involves different mechanisms and signaling pathways. Some recent studies confirmed that circular RNAs (circRNAs) have a revelatory role in controlling OS cell proliferation, invasion, and metastasis. CircRNAs consist of a covalently closed-loop structure with neither 5' nor 3' poly adenylated tail, lacking protein-encoding ability formed by back-splicing mechanisms. They mainly act as microRNA (miRNA) sponges and modulate the downstream biological processes. Up/down regulation of some circRNAs demonstrated to serve as the oncogenic factor in some tumor tissues such as OS. In this article, we review the regulatory functions of circRNAs resulting in OS cell progression or restraint and the potential for being used in vitro or in vivo as diagnostic or therapeutic biomarkers.
机译：骨质肉瘤（OS）被称为影响主要儿童和年轻成年人的恶性骨肿瘤。尽管对操作系统的治疗有所改善，但患者的整体生存率大多不满意。它涉及不同的机制和信号通路。一些最近的研究证实，圆形RNA（CircrNA）在控制OS细胞增殖，侵袭和转移方面具有令人革命的作用。 Circrnas由共价闭环结构组成，既不是5'也不是3'多腺苷酸化尾，缺乏通过背衬剪接机制形成的蛋白质编码能力。它们主要充当MicroRNA（miRNA）海绵并调节下游生物过程。一些Circrnas的上/下调证明是一些肿瘤组织如OS的致癌因子。在本文中，我们审查了CircRNA的监管职能，导致OS细胞进展或克制以及在体外使用或体内使用的可能性作为诊断或治疗生物标志物。

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