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Convex hull principle for classification and phylogeny of eukaryotic proteins

机译：真核蛋白分类和系统发育的凸壳原理

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摘要

This study quantitatively validates the principle that the biological properties associated with a given genotype are determined by the distribution of amino acids. In order to visualize this central law of molecular biology, each protein was represented by a point in 250-dimensional space based on its amino acid distribution. Proteins from the same family are found to cluster together, leading to the principle that the convex hull surrounding protein points from the same family do not intersect with the convex hulls of other protein families. This principle was verified computationally for all available and reliable protein kinases and human proteins. In addition, we generated 2,328,761 figures to show that the convex hulls of different families were disjoint from each other. The classification performs well with high and robust accuracy (95.75% and 97.5%) together with reasonable phylogenetic trees validate our methods further.
机译：该研究定量验证了与给定基因型相关的生物学特性的原理通过氨基酸的分布来确定。 为了可视化该分子生物学的中央规律，基于其氨基酸分布，每种蛋白质由250维空间中的点表示。 从同一家族中发现蛋白质聚集在一起，导致来自同一家族的凸壳周围蛋白点的原则与其他蛋白质家族的凸壳相交。 对于所有可用和可靠的蛋白激酶和人蛋白，计算地验证了该原理。 此外，我们生成了2,328,761个数字，以表明不同家庭的凸壳彼此不相交。 分类良好地表现出高且稳健的准确性（95.75％和97.5％）以及合理的系统发育树进一步验证了我们的方法。

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