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Moth-eye mimetic cytocompatible bactericidal nanotopography: a convergent design

机译：Moth-Eye模拟性细胞相容的杀菌纳米术：收敛设计

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摘要

The rapid emergence of antibiotic resistant bacteria has prompted the need for radically different approaches to combat bacterial infections. Among these, bioinspired surface topographies have emerged as an effective sustainable strategy to deter bacterial infection. This study demonstrates the bactericidal activity and cytocompatibility of the moth-eye mimetic topography produced by thermal polymer nanoimprinting. The moth-eye topography was found to have bactericidal capabilities against Gram negative and Gram positive bacteria. Electron microscopy imaging revealed the bactericidal effect caused by mechanical rupture of the bacteria wall inflicted by the topography on the adhered cells. The cytocompatibility of the surfaces was evidenced by assessing the proliferation and morphology of keratinocytes cultured on the nanotopography. The technology meets important needs in medical implant technology for materials that not only have good biocompatibility but also antibacterial properties for reducing the risk of infections and related health complications.
机译：抗生素抗性细菌的快速出现促使需要彻底不同的方法来打击细菌感染。其中，生物悬浮的表面形貌被出现为有效的可持续策略，以阻止细菌感染。本研究表明，通过热聚合物纳米压印产生的蛾眼镜模拟性推形的杀菌活性和细胞相容性。发现蛾眼睛的地形具有针对革兰氏阴性和革兰氏阳性细菌的杀菌能力。电子显微镜成像显示由粘附细胞上的地形造成的细菌壁的机械破裂引起的杀菌效果。通过评估在纳米复印件上培养的角质形成细胞的增殖和形态来证明表面的细胞偶像。该技术在医疗植入技术中满足了重要的需求，用于具有良好的生物相容性，而且还具有良好的生物相容性，而且还具有降低感染风险和相关健康并发症的抗菌性能。

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