The effect of somatostatin analogues on Ki-67 levels in GH-secreting adenomas

Selek Alev; Cetinarslan Berrin; Canturk Zeynep; Tarkun Ilhan; Hanazay Yusuf; Vural Cigdem; Anik Ihsan; Ceylan Savas

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The effect of somatostatin analogues on Ki-67 levels in GH-secreting adenomas

机译：生长抑制素类似物对GH分泌腺瘤的KI-67水平的影响

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Purpose: Somatostatin analogues (SSAs) can slow down the growth of neuroendocrine tumors. However, the mechanism remains unclear. Recent studies on patients with acromegaly suggest that SSAs may induce apoptosis, increase autophagy, and decrease cell proliferation of pituitary adenoma. Ki-67-labeling index is a marker of cellular proliferation; therefore, decreased levels are associated with inhibition of proliferation. The aim of this study was to evaluate and compare the Ki-67-labeling index of GH-secreting pituitary adenoma tissues in patients who had undergone pituitary surgery twice due to residual or recurrent tumors and had received SSA treatment between the two surgeries.

机译：目的：生长抑素类似物（SSA）可以减缓神经内分泌肿瘤的生长。但是，该机制尚不清楚。最近对患者患者的研究表明，SSA可能会诱导细胞凋亡，增加自噬和降低垂体腺瘤的细胞增殖。 Ki-67标记指数是细胞增殖的标志物; 因此，降低水平与增殖的抑制有关。本研究的目的是评估并比较GH-67标记指数，其由于残留或复发性肿瘤两次经历垂体手术的患者，并且在两个手术中接受了SSA治疗。

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来源
《Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society》 |2019年第2019期|共5页
作者
Selek Alev; Cetinarslan Berrin; Canturk Zeynep; Tarkun Ilhan; Hanazay Yusuf; Vural Cigdem; Anik Ihsan; Ceylan Savas;
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作者单位

Kocaeli Univ Fac Med Dept Endocrinol &

Metab TR-41380 Umuttepe Kocaeli Turkey;

Kocaeli Univ Fac Med Dept Endocrinol &

Metab TR-41380 Umuttepe Kocaeli Turkey;

Kocaeli Univ Fac Med Dept Endocrinol &

Metab TR-41380 Umuttepe Kocaeli Turkey;

Kocaeli Univ Fac Med Dept Endocrinol &

Metab TR-41380 Umuttepe Kocaeli Turkey;

Kocaeli Univ Fac Med Dept Internal Med Umuttepe Kocaeli Turkey;

Kocaeli Univ Fac Med Dept Pathol Umuttepe Kocaeli Turkey;

Kocaeli Univ Fac Med Dept Neurosurg Umuttepe Kocaeli Turkey;

Kocaeli Univ Fac Med Dept Neurosurg Umuttepe Kocaeli Turkey;

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原文格式 PDF
正文语种 eng
中图分类 R34;
关键词
Somatostatin analogue; Ki-67; GH-secreting adenomas; Acromegaly;

机译：生长抑素类似物;KI-67;GH-SERICING ADENOMAS;ACREMEGALY;

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1. The effect of somatostatin analogues on Ki-67 levels in GH-secreting adenomas [J] . Selek Alev, Cetinarslan Berrin, Canturk Zeynep, Growth hormone and IGF research: Official journal of the Growth Hormone Research Society and the International IGF Research Society . 2019,第期

机译：生长抑制素类似物对GH分泌腺瘤的KI-67水平的影响
2. Neurotrophins, their receptors and Ki-67 in human GH-secreting pituitary adenomas: An immunohistochemical analysis [J] . ArticoM., BianchiE., MagliuloG., International journal of immunopathology and pharmacology. . 2012,第1期

机译：分泌人生长激素的垂体腺瘤中神经营养蛋白，其受体和Ki-67的免疫组织化学分析
3. Neurotrophins, Their Receptors and KI-67 in Human GH-Secreting Pituitary Adenomas: An Immunohistochemical Analysis [J] . M. Artico, E. Bianchi, G. Magliulo, International journal of immunopathology and pharmacology. . 2012,第1期

机译：GH分泌型垂体腺瘤中神经营养蛋白及其受体和KI-67的免疫组织化学分析
4. COMPARISON OF SOMATOSTATIN ANALOGUES AND CONVENTIONAL IMAGING MODALITIES FOR STAGING OF CANINE B-CELL LYMPHOMA. [C] . Kimberly Ringen, Micheal Lewis, Jimmy Lattimer, Annual Conference of the Veterinary Cancer Society . 2009

机译：生长抑素类似物与常规成像方式的比较犬B细胞淋巴瘤分期。
5. Drug stability and release kinetics of a somatostatin analogue formulated in polymeric biodegradable microspheres. [D] . Murty, Santos Boddapati. 2003

机译：在聚合物可生物降解的微球中配制的生长抑素类似物的药物稳定性和释放动力学。
6. Somatostatin Receptor Expression in GH-Secreting Pituitary Adenomas Treated with Long-Acting Somatostatin Analogues in Combination with Pegvisomant [O] . Sanne E. Franck, Federico Gatto, Aart Jan van der Lely, -1

机译：长效生长抑素类似物联合培维索孟治疗GH分泌型垂体腺瘤中生长抑素受体的表达
7. Somatostatin Receptor Expression in GH-Secreting Pituitary Adenomas Treated with Long-Acting Somatostatin Analogues in Combination with Pegvisomant [O] . Franck, Sanne E, Gatto, Federico, van der Lely, Aart Jan, 2016

机译：长效生长抑素类似物联合培维索孟治疗GH分泌型垂体腺瘤中生长抑素受体的表达

The effect of somatostatin analogues on Ki-67 levels in GH-secreting adenomas

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