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首页> 外文期刊>Graefe's archive for clinical and experimental ophthalmology: Albrecht von Graefes Archiv fur klinische und experimentelle Opthalmologie >Antibacterial and physical properties of a novel sonochemical-assisted Zn-CuO contact lens nanocoating
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Antibacterial and physical properties of a novel sonochemical-assisted Zn-CuO contact lens nanocoating

机译：一种新颖的儿学辅助Zn-CuO隐形眼镜纳米晶的抗菌和物理性质

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PurposeThis work examined the antibacterial and physical effects of a novel Zn-CuO nanocoating applied on a silicone hydrogel contact lens.MethodsZn-CuO coating of PureVision balafilcon-A soft contact lenses (Bausch&Lomb, Rochester, NY) was performed by sonochemical deposition using a high-intensity ultrasonic horn. Non-coated PureVision lenses served as a control in all experiments. Adhesion assays for P. aerueginosa and S. epidermidis to the coated lenses were performed to identify the minimal coating concentration which still possessed antibacterial activity. Lens water content, oxygen transfer light transfer, leaching, and electron microscopy studies were performed using this concentration.ResultsCoated lenses showed 3-5 log reductions in adhesion of both species. The lowest tested coating concentration of 0.02wt% led to a log reduction of 3.251.25 of P. aeruginosa CFU/lens (P=0.007) and a log reduction of 4.37 +/- 0.75 of S. epidermidis (p=0.0007). Using this coating concentration, water content (36%, 33.6%), oxygen transfer (87.22 +/- 10.96, 92.18 +/- 2.38, x10(-11)(cm(2)/s)(mlO(2))/(mlxmmHg)), p=0.12), and light transfer properties did not differ significantly between the coated and the control contact lenses. In the range of 380-780nm wavelength, the coated lenses transmitted 96.47 +/- 1.52% while the control lenses transmitted 97.36 +/- 1.35%. The corresponding values for the range of 300-380nm wavelength were 79.343 +/- 8.754 and 80.169 +/- 1.35. Leaching studies for 0.5mM coated lenses have demonstrated the excellent stability of the coating with the release of only 0.005% of the coating after 1week of exposure to the test solution.Conclusionp id=Par4 Sonochemical-assisted nanocoating of contact lenses showed significant and consistent antibacterial activity while preserving the basic properties of a silicone hydrogel contact lens.
机译：用高素化学沉积使用高度使用高度沉积，研究了在硅氧烷水凝胶隐形眼镜上施加在硅氧烷水凝胶隐形眼镜的新型Zn-CuO纳米核的抗菌和物理效果。用高素化学沉积进行软面沉积（Bausch＆Lomb，罗切斯特，纽约）的柔软隐形眼镜（Bausch＆Lomb，罗切斯特。 - 强度超声喇叭。非涂层的PureVision镜片在所有实验中都是控制。对涂覆透镜的P. AerueginoSA和S.表皮的粘附测定进行鉴定仍然具有抗菌活性的最小涂层浓度。使用该浓度进行镜片含水量，氧转印光转移，浸出和电子显微镜研究。涂覆涂层透镜显示出3-5个对两种粘合性的对数减少。 0.02wt％的最低测试涂层浓度导致P.铜绿假单胞菌/晶状体/透镜（P = 0.007）的3.251.25的对数减少和4.37 +/- 0.75的S.Peidermidis（P = 0.0007）。使用该涂层浓度，水含量（36％，33.6％），氧转印（87.22 +/- 10.96,92.18 +/- 2.38，x10（-11）（cm（2）/ s）/（mlo（2））/ （MLXMMHG）），P = 0.12），并且在涂覆和控制隐形眼镜之间的光传递特性没有显着差异。在380-780nm波长的范围内，涂层镜片传输96.47 +/- 1.52％，而控制镜片传输97.36 +/- 1.35％。 300-380nm波长范围的相应值为79.343 +/- 8.754和80.169 +/- 1.35。 0.5mm涂层透镜的浸出研究表明，涂层的优异稳定性在接触测试溶液后仅用0.005％的涂层释放.Clusionp ID = PAR4的隐形眼镜的多种子化学辅助纳米织物显示出显着且一致的抗菌剂活动同时保留有机硅水凝胶隐形眼镜的基本性质。

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