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首页> 外文期刊>Graefe's archive for clinical and experimental ophthalmology: Albrecht von Graefes Archiv fur klinische und experimentelle Opthalmologie >Alteration of choroidal vascular structure in diabetic macular edema
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Alteration of choroidal vascular structure in diabetic macular edema

机译：糖尿病黄斑水肿中脉络膜血管结构的改变

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Purpose The aim of this study was to analyze choroidal structures in healthy subjects and patients with/without diabetic macular edema (DME). Methods This was a retrospective observation case control study. Four hundred and two eyes of patients with diabetes mellitus (DM), and 124 age-matched eyes of healthy subjects were enrolled in this study. DM patients were divided into 3 groups: presence of central-involved (CI) DME (n = 81) and nonCI-DME/non-DME (n = 321), based on OCT findings. Central choroidal thickness (CCT) and total choroidal, luminal, and stromal areas were determined using EDI-OCT and a binarization method, respectively. The luminal area expressed as a ratio of the total choroidal area was defined as the L/C ratio. Results DM eyes showed a significantly lower L/C ratio than control eyes, whereas there was no significant difference in CCT or total choroidal, luminal, or stromal areas. There was no significant difference between CI-DME and non-DME groups in HbA1c, blood pressure, dyslipidemia, or renal function. CCT and total choroidal, luminal, and stromal areas were significantly greater in the CI-DME group than non-DME group (each P < 0.05). Conclusions These results suggest that CCT was thickened in the presence of DME, associated with both increased luminal and stromal areas, which might be related to the pathology of DME.
机译：目的本研究的目的是分析健康受试者和患者/不含糖尿病黄斑水肿（DME）的脉络膜结构。方法这是一个回顾性观察案例控制研究。患有糖尿病患者（DM）的四百和两只眼睛和124岁的健康受试者的年龄匹配的眼睛均被纳入本研究。 DM患者分为3组：基于OCT调查结果，分为3组：存在中涉及的中枢（CI）DME（n = 81）和非CI-DME /非DME（n = 321）。使用EDI-OCT和二值化方法测定中央脉络膜厚度（CCT）和总脉络膜，腔和基质区域。表示为总脉络膜区域的比例的腔面积定义为L / C比。结果DM眼显示出比对照眼显着降低L / C比，而CCT或总脉络膜，腔室或基质区域没有显着差异。 CI-DME和HBA1C，血压，血脂血症或肾功能中没有显着差异。 CC-DME组在CI-DME组中，CCT和总脉络膜，腔和基质区域显着大于非DME组（每P <0.05）。结论这些结果表明，CCT在DME存在下增厚，与增加的腔内和基质区域有关，这可能与DME的病理相关。

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