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Effect of moderate and high intensity chronic exercise on the pancreatic islet morphometry in healthy rats: BDNF receptor participation

机译：中等和高强度慢性运动对健康大鼠胰岛形态学的影响：BDNF受体参与

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The function and morphology of β-cells is largely dependent on insulin demand. As β-cells cover a bigger cell proportion in pancreas islets, changes of insulin producer cells affect the whole pancreatic islet morphology. Growth factors as the neurotrophins regulate the pancreas physiology, besides; physical exercise increases insulin sensitivity, and further modifies brain derived neurotrophic factor (BDNF) concentration in plasma. The aim of this study was to investigate the effects of chronic exercise (running in a treadmill for 8 weeks) intensity on pancreatic islet morphometry in healthy state. The BDNF receptor effect on the pancreatic islet morphometry was also evaluated. Adult male Wistar rats were divided in 6 groups: Control (C); moderate intensity training (MIT); high intensity training (HIT) did not treat with BDNF receptor inhibitor (K252a), and C, MIT and HIT treated with K252a. The results shown that chronic exercise induces β-cells hypertrophy without BDNF receptor participation. On the other hand, the moderate exercise increases the number of β cells per islet; the last effect does not require TrkB participation. In sedentary conditions, the K252a treatment reduced the β-cell density. Exercise intensity has differential effects on pancreas islet morphometry in healthy model; furthermore, BDNF receptor plays a role to maintain the amount of β-cells in sedentary state.
机译：β细胞的功能和形态在很大程度上取决于胰岛素需求。由于β细胞在胰岛胰岛中覆盖更大的细胞比例，因此胰岛素生产者细胞的变化会影响整个胰岛素的形态。除了神经营养素调节胰腺生理学的生长因素。体育锻炼会增加胰岛素敏感性，并进一步改变血浆中的脑衍生的神经营养因子（BDNF）浓度。本研究的目的是探讨慢性运动（在跑步机中运行8周的跑步机8周）强度对健康状态的胰岛形态。还评估了对胰岛形态学的BDNF受体作用。成年男性Wistar大鼠分为6组：控制（C）;中等强度训练（麻省理工学院）;高强度训练（HIT）与BDNF受体抑制剂（K252A）和C，MIT和用K252A处理的培训进行治疗。结果表明，慢性锻炼诱导β-细胞肥大而没有BDNF受体参与。另一方面，中等运动增加了每个胰岛的β细胞的数量;最后效果不需要TRKB参与。在久入条件下，K252A治疗降低了β细胞密度。运动强度对健康模型的胰腺胰岛形态学具有差异影响;此外，BDNF受体发挥作用以维持久坐状态下的β细胞量。

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