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首页> 外文期刊>Glia >Tanycytes and a Differential Fatty Acid Metabolism in the Hypothalamus
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Tanycytes and a Differential Fatty Acid Metabolism in the Hypothalamus

机译：丘陵和下丘脑中的差异脂肪酸代谢

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摘要

Although the brain controls all main metabolic pathways in the whole organism, its lipid metabolism is partially separated from the rest of the body. Circulating lipids and other metabolites are taken up into brain areas like the hypothalamus and are locally metabolized and sensed involving several hypothalamic cell types. In this study we show that saturated and unsaturated fatty acids are differentially processed in the murine hypothalamus. The observed differences involve both lipid distribution and metabolism. Key findings were: (i) hypothalamic astrocytes are targeted by unsaturated, but not saturated lipids in lean mice; (ii) in obese mice labeling of these astrocytes by unsaturated oleic acid cannot be detected unless -oxidation or ketogenesis is inhibited; (iii) the hypothalamus of obese animals increases ketone body and neutral lipid synthesis while tanycytes, hypothalamic cells facing the ventricle, increase their lipid droplet content; and (iv) tanycytes show different labeling for saturated or unsaturated lipids. Our data support a metabolic connection between tanycytes and astrocytes likely to impact hypothalamic lipid sensing.
机译：虽然脑控制了整个生物体中的所有主要代谢途径，但其脂质代谢部分与身体的其余部分部分分离。将循环脂质和其他代谢物溶于丘脑等脑区域，并在局部代谢和感测，涉及几种下丘脑类型。在该研究中，我们表明饱和和不饱和脂肪酸在鼠下丘脑中差异地处理。观察到的差异涉及脂质分布和代谢。关键发现是：（i）下丘脑星形胶质细胞通过不饱和的，但在瘦小鼠中没有饱和脂质靶向; （ii）在肥胖的小鼠中，除非抑制 - 氧化或酮酮，否则不能检测到不饱和油酸的星形胶质细胞; （iii）肥胖动物的下丘脑增加酮体和中性脂质合成，而Tanycytes，面向心室的下丘脑细胞，增加了它们的脂质液滴含量; （IV）Tanycytes针对饱和或不饱和脂质显示出不同的标记。我们的数据支持Tanycytes和星形胶质细胞之间的代谢联系可能会影响下丘脑脂质传感。

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