...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Glia >Endogenous GABA Controls Oligodendrocyte Lineage Cell Number, Myelination, and CNS Internode Length
【24h】

Endogenous GABA Controls Oligodendrocyte Lineage Cell Number, Myelination, and CNS Internode Length

机译：内源性GABA控制少突胶质细胞谱系细胞数，髓鞘和CNS节水长度

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adjusting the thickness and internodal length of the myelin sheath is a mechanism for tuning the conduction velocity of axons to match computational needs. Interactions between oligodendrocyte precursor cells (OPCs) and developing axons regulate the formation of myelin around axons. We now show, using organotypic cerebral cortex slices from mice expressing eGFP in Sox10-positive oligodendrocytes, that endogenously released GABA, acting on GABA(A) receptors, greatly reduces the number of oligodendrocyte lineage cells. The decrease in oligodendrocyte number correlates with a reduction in the amount of myelination but also an increase in internode length, a parameter previously thought to be set by the axon diameter or to be a property intrinsic to oligodendrocytes. Importantly, while TTX block of neuronal activity had no effect on oligodendrocyte lineage cell number when applied alone, it was able to completely abolish the effect of blocking GABA(A) receptors, suggesting that control of myelination by endogenous GABA may require a permissive factor to be released from axons. In contrast, block of AMPA/KA receptors had no effect on oligodendrocyte lineage cell number or myelination. These results imply that, during development, GABA can act as a local environmental cue to control myelination and thus influence the conduction velocity of action potentials within the CNS.
机译：调节髓鞘鞘的厚度和髁间长度是调整轴突的传导速度以匹配计算需求的机制。 oligodendrocyte前体细胞（OPCS）与显影轴突之间的相互作用调节骨髓膜周围的轴突。我们现在展示使用在SOX10阳性寡核细胞中表达EGFP的小鼠的单型脑皮质切片，其在GABA（A）受体上作用的内源性释放的GABA大大减少了少突胚细胞谱系细胞的数量。少突胶质细胞数的降低与髓鞘量的减少相关，而且还有髓中度的增加，先前认为由轴突直径设定的参数或是少偶突茂细胞的属性。重要的是，当单独施用时，虽然TTX神经元活性对少突胚细胞谱系细胞数没有影响，但是它能够完全取消阻断GABA（A）受体的影响，表明通过内源性GABA对髓鞘产生的控制可能需要允许允许的因素从轴突中释放。相反，AMPA / KA受体块对少突胚细胞谱系细胞数或髓鞘产生没有影响。这些结果意味着，在开发过程中，加巴可以作为当地环境提示来控制髓鞘，从而影响CNS内的动作电位的传导速度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号