• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Fibers and Polymers >Physicochemical and Antibacterial Characterization of Nanofibrous Wound Dressing from Silk Fibroin-polyvinyl Alcohol- Elaeagnus Angustifolia Extract
【24h】

Physicochemical and Antibacterial Characterization of Nanofibrous Wound Dressing from Silk Fibroin-polyvinyl Alcohol- Elaeagnus Angustifolia Extract

机译：丝纤维素 - 聚乙烯醇 - 伊古氏菌植物植物植物植物植物的纳米纤维伤口敷料的物理化学和抗菌特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The herbal drug incorporated nanofibers with potential accelerating wound healing has become a promising wound dressing to treat wounds. The present research aimed to study the effects of adding different amounts of Elaeagnus Angustifolia (EA) extract on physical, mechanical, and biological properties of silk fibroin-polyvinyl alcohol (SF-PVA) nanofibers. Thus, different electrospun mats were made by changing the SF to the EA ratio. The successful incorporation of EA in SF-PVA nanofibers was confirmed by Fourier transform infrared spectroscopy (FTIR). No obvious change was observed in the mean fiber diameter except for EA/SF ratio 1:3. Also, mechanical properties results showed that the ultimate tensile strength of samples dropped from 9 +/- 0.8 MPa to 2.50 +/- 0.03 MPa with decreasing SF amount. The in vitro release studies indicated that the fickian diffusion controlled the EA release profile and it was faster in the nanofibers containing more EA. Furthermore, the addition of EA into the nanofibrous dressings improved their antioxidant activity as well as antibacterial activity against both gram-positive (S. aureus) and gram- negative (E. coli) bacteria. Cell viability was also measured using fibroblast cells cultured on prepared dressings and results proved that the higher amounts of EA have a significant impact on cell viability. These findings suggest the advantages of EA as an additive to regulate cell behavior and for skin tissue regeneration.
机译：草药药物掺入具有潜在加速伤口愈合的纳米纤维已成为一种有前途的伤口敷料治疗伤口。目前的研究旨在研究添加不同量的Elaeagnus Angustifolia（EA）提取物对丝素蛋白 - 聚乙烯醇（SF-PVA）纳米纤维的物理，机械和生物学性质的影响。因此，通过将SF改变为EA比来制备不​​同的电纺垫。通过傅里叶变换红外光谱（FTIR）证实了在SF-PVA纳米纤维中成功掺入EA。在平均纤维直径中没有观察到明显的变化，除了EA / SF比例1：3。此外，机械性能结果表明，样品的最终拉伸强度从9 +/- 0.8MPa降至2.50 +/- 0.03MPa，随着SF量的降低。体外释放研究表明，Fickian扩散控制了EA释放曲线，并且在含有更多EA的纳米纤维中更快。此外，将EA加入纳米纤维敷料改善其抗氧化活性以及针对革兰氏阳性（S. aureus）和革兰氏阴性（大肠杆菌）细菌的抗菌活性。还使用在制备的敷料上培养的成纤维细胞测量细胞活力，并证明了较高量的EA对细胞活力产生显着影响。这些研究结果表明EA作为添加剂来调节细胞行为和皮肤组织再生的优点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号