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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Evaluation of the isoflavones and estrogen effects on the rat adrenal
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Evaluation of the isoflavones and estrogen effects on the rat adrenal

机译：对大鼠肾上腺素的异黄酮和雌激素效应的评价

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摘要

The aim of this study was to evaluate the morphometry and the gene expression of Ki-67, VEGF and caspase 3 and the stress oxidative in the adrenal gland of ovariectomized rats treated with estrogen or isoflavones. We used 15 Wistar rats ovariectomized treated with isoflavones or estrogen during 30days. At the end of the treatment, the left adrenal gland was removed for subsequent histological studies and the right was used to evaluate gene expression of angiogenesis (VEGF-A), cell proliferation (Ki-67), apoptose (caspase 3 clivated) and oxidative stress. Treatment with estrogen showed a largest increase in the layers of the adrenal cortex than with isoflavones. These hypertrofic effects agree with higher expression elevation of Ki67 and VEGF, which did not occur with the caspase 3, indicating that isoflavones have great proliferative effect on the adrenal gland. Similar results were also observed on superoxide quantification show that isoflavone has a protective effect against oxidative stress. Our results indicate positively the trophic therapeutic potential of isoflavones has a protective effect and can contribute to the development of effective therapies to decrease the symptoms of menopause.
机译：该研究的目的是评估Ki-67，VEGF和Caspase 3的形态学和基因表达以及雌激素或异黄酮处理的卵巢切除大鼠肾上腺腺体中的应力氧化。我们在30天内使用了用异黄酮或雌激素治疗的15只Wistar大鼠。在治疗结束时，除去左肾腺体被除去后续的组织学研究，并且右边用于评估血管生成（VEGF-A），细胞增殖（Ki-67），临氢（Caspase 3 Clivated）和氧化剂的基因表达。压力。雌激素治疗表现出肾上腺皮质层的最大增加而不是与异黄酮相比。这些超细效应与ki67和Vegf的更高表达升高一致，该ki67和VEGF与胱天蛋白酶3没有发生，表明异黄酮对肾上腺具有很大的增殖作用。在超氧化物定量方面也观察到类似的结果表明异黄酮对氧化应激具有保护作用。我们的结果表明，异黄酮的营养治疗潜力具有积极性，有助于开发有效疗法，以降低更年期的症状。

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