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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Association between polycystic ovary syndrome and the risk of stroke and all-cause mortality: insights from a meta-analysis
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Association between polycystic ovary syndrome and the risk of stroke and all-cause mortality: insights from a meta-analysis

机译：多囊卵巢综合征与卒中风险与脑卒中风险与脑卒中的风险：荟萃分析的见解

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Many epidemiologic literatures have investigated the link between PCOS and long-term stroke risk and all-cause mortality, but the results are surprisingly conflicting. A meta-analysis was performed to examine the link between polycystic ovary syndrome (PCOS) and the risk of stroke, death from any cause, and assessed whether BMI might explain a higher risk of stroke. We searched the PUBMED, EMBASE, and Cochrane Library databases with no restrictions. Nine Cohort studies were identified, involving a total of 237,647 subjects. Compared with those without PCOS, subjects with PCOS were significantly associated with a increased risk of developing stroke (OR=1.36; 95% CI 1.09-1.70; p=.007). However, no significant association was observed between PCOS and all-cause death (OR=1.21; 95% CI 0.88-1.66; p=.25). Moreover, after pooling the five studies with risk estimates adjusted for BMI, the association between PCOS and stroke was slightly attenuated, although the odds ratios did not reach statistical significance (OR=1.24; 95%CI 0.98-1.59). In conclusion, PCOS is associated with significant increased risk for stroke, while there is no consistent evidence to indicate that PCOS influences all-cause death outcomes. Increased BMI is an important contributor to the relationship between PCOS and stroke risk. Further study is needed to clarify which subgroups of subjects with the PCOS are at higher risk for stroke and should focus on developing reliable device for risk stratification.
机译：许多流行病学文献研究了PCOS和长期卒中风险之间的联系和全导致死亡率，但结果令人惊讶地矛盾。进行META分析以检查多囊卵巢综合征（PCOS）之间的联系以及来自任何原因的中风，死亡的风险，并评估BMI是否可能解释卒中风险更高。我们搜索了PubMed，Embase和Cochrane库数据库，没有限制。确定了九项研究，涉及共237,647名受试者。与没有PCOS的那些相比，具有PCOS的受试者显着与发育中风的风险增加（或= 1.36; 95％CI 1.09-1.70; P = .007）。然而，在PCOS和全因死亡（或= 1.21; 95％CI 0.88-1.66; P = .25）之间没有观察到显着关联。此外，在对BMI进行调整的风险估计的五项研究后，PCOS与中风之间的关联略微衰减，尽管差异比率没有达到统计学意义（或= 1.24; 95％CI 0.98-1.59）。总之，PCOS与中风的风险显着增加，而没有一致的证据表明PCOS影响全因死的死亡结果。 BMI增加是PCOS与中风风险之间关系的重要贡献者。需要进一步研究以澄清与PCOS的受试者的亚组处于较高风险，并且应该专注于开发风险分层的可靠装置。

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