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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Gender-, age- and time-dependent dosing of growth hormone in adults - real-world data from a decade of clinical practice in Germany
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Gender-, age- and time-dependent dosing of growth hormone in adults - real-world data from a decade of clinical practice in Germany

机译：成人中生长激素的性别 - ，年龄和时间依赖于生长激素 - 来自德国临床实践十年的现实世界数据

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摘要

We evaluated treatment patterns and gender-dependent dosing of growth hormone (GH) substitution in adults with GH deficiency (AGHD). Data on GH dose were collected (2003-2013) from 509GH-treated patients (mean age: 48.9years; 47% female) enroled in the observational German NordiWin study (NCT01543880). The impact of gender, age, treatment duration and calendar year on GH treatment patterns was evaluated by multiple regression analysis. Mean (SD) baseline GH dose (mg/day) was similar between females (0.25 [0.19] and males (0.24 [0.15]), but increased with treatment duration (at year 10, 0.55 [0.48] and 0.31 [0.09] in females and males, respectively), reflecting patient dose titration. GH dose increased more in females than males during treatment; this was statistically significant in years 2-6 (p<0.05). Over the 10-year study period, a time trend of an overall estimated GH dose increase by 0.06mg/day (females) and decrease by 0.07mg/day (males) was shown; this interaction of gender and calendar year was significant (p<0.0001). In both genders, overall GH dose decreased with increasing age (p<0.0001). Our study confirms that females and younger patients require higher GH doses compared with males and older patients.
机译：我们评估了GH缺乏（AGHD）在成人中的生长激素（GH）替代的治疗模式和性别依赖性剂量。收集GH剂量的数据（2003-2013）来自509GH治疗的患者（平均年龄：48.9年; 47％的女性）在观察德国Nordiwin研究中（NCT01543880）。通过多元回归分析评估了性别，年龄，治疗持续时间和日历年对GH治疗模式的影响。平均值（SD）基线GH剂量（Mg / Day）在雌性之间相似（0.25 [0.25]和雄性（0.24 [0.24 [0.15]），但随治疗持续时间增加（在10时，0.55 [0.48]和0.31 [0.09]分别反映患者剂量滴定的女性和男性。治疗期间的女性比男性更多的女性增加了更多的女性;这在2-6年的统计学意义（P <0.05）。在10年的研究期间，时间趋势总估计的GH剂量增加了0.06mg /天（女性）并显示0.07mg /天（男性）减少;这种性别和日历年的互动很大（P <0.0001）。在两种性别，总体GH剂量减少随着年龄的增加（P <0.0001）。我们的研究证实，与男性和老年患者相比，女性和年轻患者需要更高的GH剂量。

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