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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Metabolic inflexibility in women with polycystic ovary syndrome: a systematic review
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Metabolic inflexibility in women with polycystic ovary syndrome: a systematic review

机译：具有多囊卵巢综合征的女性的代谢屈服性：系统评价

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Polycystic ovary syndrome (PCOS) is a risk factor for dysglycemia, insulin resistance, and type 2 Diabetes Mellitus (T2DM). Inefficient energy oxidation, metabolic inflexibility, is a marker of blunted metabolism. We conducted a systematic review on metabolic inflexibility in women with PCOS. We searched MEDLINE, EMBASE and Cochrane central (inception-October 2018) for studies evaluating metabolic inflexibility and reporting on changes in Respiratory Quotient (Delta RQ). We extracted data and assessed quality using The Newcastle-Ottawa Scale. We included five prospective cohort studies (461 women). Three compared PCOS women to unaffected subjects, one to women with obesity or T2DM, and one to adolescent girls; all had medium quality. Three studies showed higher metabolic inflexibility in women with PCOS (Delta RQ range 0.05-0.098) compared to unaffected subjects. Women with PCOS had similar metabolic inflexibility compared to those with T2DM (Delta RQ 0.05 +/- 0.03 vs 0.06 +/- 0.04, p = .98) and obesity (p = .06). Inflexibility was higher in hyperandrogenemic women with PCOS (Delta RQ 0.091 +/- 0.060 vs 0.120 +/- 0.010, p = .014). Delta RQ was lower in PCOS women with insulin resistance vs those with normal insulin sensitivity (0.04 +/- 0.02 vs. 0.07 +/- 0.04, p = .007). In conclusion, women with polycystic ovary syndrome appear to have higher metabolic inflexibility associated with hyperandrogenemia and insulin resistance.
机译：多囊卵巢综合征（PCOS）是患有血糖，胰岛素抵抗和2型糖尿病（T2DM）的危险因素。能量氧化效率低，代谢屈服性是一种易患代谢的标志物。我们对PCOS妇女的代谢粘度进行了系统综述。我们搜索了Medline，Embase和Cochrane Central（2018年10月），用于评估代谢不灵活性和报告呼吸器（Delta RQ）的改变。我们使用纽卡斯尔 - 渥太华规模提取数据并评估质量。我们包括五项前瞻性队列研究（461名妇女）。三个比较的PCOS女性与未受影响的科目，一个对肥胖或T2DM的女性，也是一个对青少年的女孩;所有人都有中等品质。与未受影响的受试者相比，三项研究表明，PCOS（Delta RQ范围0.05-0.098）的女性较高的代谢屈服。与具有T2DM的人相比，PCOS的女性具有相似的代谢粘度性（Delta RQ 0.05 +/- 0.03 Vs 0.06 +/- 0.04，P = .98）和肥胖（P = .06）。 Hyposey女性的抑制性高（Delta RQ 0.091 +/- 0.060 Vs 0.120 +/- 0.010，P = .014）。三角洲RQ患有胰岛素抗性的胰岛素血液血液血液血液血液敏感性患者（0.04 +/- 0.02，P = .007）。总之，具有多囊卵巢综合征的妇女似乎具有与高吲哚血症和胰岛素抵抗相关的更高的代谢粘度。

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