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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility
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Alternation of ten-eleven translocation 1, 2, and 3 expression in eutopic endometrium of women with endometriosis-associated infertility

机译：十一十一易位1,2和3患有子宫内膜异位症相关不育症的妇女陪伴性子宫内膜的交替

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Little is known about the differences in ten-eleven translocation 1, 2, and 3 (TET1-3) expression in the endometrial phases in eutopic endometrium from infertile women with endometriosis (IWE) and fertile women without endometriosis (FW). Using RT-qPCR and western blot analysis, we assessed the TET expression in the mid-follicular and mid-luteal phases in eutopic endometrium from IWE (n = 38) and FW (n = 18). Both IWE and FW underwent laparoscopic and histological examinations for endometriosis. In the mid-luteal eutopic endometrium in IWE, compared to that of FW, we found significantly reduced levels of TET1 transcripts and proteins (p = .001 and p = .003, respectively) at the severity stage of I/II (p = .029 and p = .003, respectively) and transcripts only at the severity stage of III/IV (p = .003). In the mid-follicular eutopic endometrium of IWE, compared to that of FW, there was a statistically significant reduction in TET2 transcript levels at the severity stage of III/IV (p = .037). Compared to the mid-follicular endometrium, we found a statistically significant increase in TET3 transcript levels during the mid-luteal phase in the eutopic endometrium of all IWE (p = .034) and in the severity stage of III/IV (p = .025). We observed a change in the expression levels of TET1-3 in the eutopic endometrium of IWE.
机译：关于来自因子源症（IWE）和肥沃女性的不育妇女的子宫内膜子宫内膜中的十一易位1,2和3（TET1-3）表达的差异毫无熟悉，没有子宫内膜异位症（IWE）和没有子宫内膜异位症（FW）的肥沃女性。使用RT-QPCR和Western印迹分析，我们评估了来自IWE（n = 38）和FW（n = 18）的抑制子宫内膜中的中毛囊和中滞相中的TET表达。 IWE和FW都经历了腹腔镜和子宫内膜异位症的组织学检查。在IWE中的中脑抑板子宫内膜中，与FW相比，我们发现在I / II的严重性阶段，TET1转录物和蛋白质（P = .001和p = .003分别）显着降低了（P =分别在III / IV的严重性阶段（P = .003），分别为029和p = .003。在IWE的中滤泡子宫内膜中，与FW相比，III / IV的严重性阶段的TET2转录水平存在统计学上显着降低（p = .037）。与中毛子宫内膜相比，我们发现在所有IWE（P = .034）的抑板子宫内患者中的中肺相位和III / IV的严重性阶段的中缺口期间TET3转录物水平的统计学上显着增加（P =。 025）。我们观察到IWE的抑制子宫内膜中TET1-3表达水平的变化。

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