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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Progesterone for hot flush and night sweat treatment - effectiveness for severe vasomotor symptoms and lack of withdrawal rebound
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Progesterone for hot flush and night sweat treatment - effectiveness for severe vasomotor symptoms and lack of withdrawal rebound

机译：孕酮为热冲洗和夜间汗水处理 - 严重血管传离症状的有效性和缺乏退出反弹

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摘要

A controlled trial recently showed that oral micronized progesterone (Progesterone, 300 mg at h.s. daily) was effective for vasomotor symptoms (VMS) in 133 healthy early postmenopausal women. Here, we present subgroup data in women with severe VMS (50 VMS of moderate-severe intensity/wk) and also 1-mo withdrawal study outcomes. Women with severe VMS (n = 46) resembled the full cohort but experienced 10 VMS/d of 3 of 4 intensity. On therapy, the progesterone VMS number (#) decreased significantly more than placebo # to 5.5/day (d) versus 8/d (ANCOVA -2.0 95% CI: -3.5 to -0.4). Just after trial mid-point, a withdrawal substudy (D/C) was added - 56 women were invited and 34 (61%) took part (progesterone 17; placebo 17). Those in the D/C cohort resembled the whole cohort. On stopping, VMS gradually increased - at D/C week 4, on progesterone, VMS daily # reached 78% and significantly less than baseline (-3.0 to -0.8) but placebo VMS # did not differ from run-in. In summary, progesterone is effective for severe VMS and does not cause a rebound increase in VMS when stopped. That progesterone may be used alone for severe VMS and unlike estrogen does not appear to cause a withdrawal rebound increases VMS treatment options.
机译：受控试验最近表明口腔微粉化孕酮（孕酮，300mg，每日300毫克）对133例健康早期绝经妇女的血管运动症状（VMS）有效。在这里，我们呈现严重VMS（50 VM的中度严重强度/ WK）和1-Mo撤离研究结果的女性亚组数据。严重VMS（n = 46）的女性类似于全队列，但经历了10个强度的10个VMS / D.在治疗中，孕酮VMS数（＃）显着降低了安慰剂＃至5.5 /天（d）（D）（ANCOVA -2.0 95％CI：-3.5至-0.4）。在试验中期后，加入撤离替换（D / C） - 邀请56名妇女，34名（61％）参加（孕酮17;安慰剂17）。 D / C队列中的那些类似于整个队列。在停止时，VMS逐渐增加 - 在D / C第4周，在黄体酮上，VM每日＃达到78％，明显小于基线（-3.0至-0.8），但安慰剂VMS＃与inl-in没有不同。总之，孕酮对于严重的VM有效，并且在停止时不会导致VM的反弹增加。孕酮可以单独使用，用于严重的VM，不同于雌激素似乎不会导致撤回反弹增加VMS治疗方案。

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