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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Effects of Roux-en-Y gastric bypass surgery on eating behaviour and allopregnanolone levels in obese women with polycystic ovary syndrome
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Effects of Roux-en-Y gastric bypass surgery on eating behaviour and allopregnanolone levels in obese women with polycystic ovary syndrome

机译：Roux-Zh-Y胃旁路手术对多囊卵巢综合征肥胖妇女饮食行为和亚丙醇龙水平的影响

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Polycystic ovary syndrome (PCOS) is associated with abnormal eating habits. We examined whether surgical treatment affected allopregnanolone levels and eating behaviour in nine women with PCOS who qualified for Rou-en-Y gastric bypass surgery. Blood samples were obtained to measure sex-hormone-binding globulin, total testosterone, progesterone, and allopregnanolone, and eating behaviour was evaluated using the Three-Factor Eating Questionnaire before surgery and at 6 and 12 months after surgery. Body mass index and total testosterone levels decreased, and progesterone and sex-hormone-binding globulin levels increased after bariatric surgery compared with pre-surgical values. In patients with anovulatory menstrual cycles, both the serum allopregnanolone level and the allopregnanolone/proges-terone ratio were unchanged after surgery. The patients had high uncontrolled and emotional eating scores, and low cognitive restraint scores before surgery, and these scores had improved significantly at 6 and 12 months after surgery. The presurgical allopregnanolone levels were significantly correlated with uncontrolled eating. In conclusion, these results suggest that allopregnanolone appear to be part of the mechanism underlying the abnormal eating behaviour of obese PCOS patients by causing the loss of control over food intake. Roux-en-Y gastric bypass surgery can improve eating behaviour and clinical symptoms, and may facilitate weight loss in obese women with PCOS.
机译：多囊卵巢综合征（PCOS）与异常的饮食习惯有关。我们检查了手术治疗是否影响了九名妇女的艾滋治南龙水平和饮食行为，PCOS患有Rou-Zh-Y胃旁路手术。获得血液样品以测量性激素结合球蛋白，总睾酮，孕酮和亚铝醇，并使用手术前的三因素和手术后6月和12个月评估饮食行为。体重指数和总睾酮水平降低，与前手术值相比，雌激素和性激素结合球蛋白水平增加。在患有术治疗月经循环的患者中，手术后血清亚丙醇醇水平和亚铝醇酮/杂种术术保持不变。患者在手术前的不受控制和情感饮食评分高，并且在手术前的严重约束评分，并且这些评分在手术后6和12个月内显着改善。前丙烯酸盐水平与不受控制的饮食显着相关。总之，这些结果表明，通过导致对食物摄入量丧失的损失，奥基康康尼醇似乎是肥胖PCOS患者异常饮食行为的一部分。 Roux-Zh-Y胃旁路手术可以改善饮食行为和临床症状，并可促进肥胖女性与PCOS的体重减轻。

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