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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Elevation of C-reactive protein during the luteal phase in healthy adolescents
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Elevation of C-reactive protein during the luteal phase in healthy adolescents

机译：健康青少年肺癌期间C反应蛋白的升高

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Introduction: Variations in inflammatory markers have been reported in adult women during the luteal phase, but whether these findings are observed during adolescence is unknown. We postulate that higher ultrasensitive C-reactive protein (usCRP) and lower 2-hydroxyestrone (2OHE) levels, an estrogen metabolite with cardioprotective actions, are present during the luteal phase in young women. Aim: To evaluate usCRP levels during the menstrual cycle and to determine its association with 2OHE and 16alpha-hydroxyestrone (16OHE) in adolescents. Methods: Healthy postmenarcheal adolescents (N=37) were studied during one menstrual cycle in follicular phase (FP) and luteal phase-like period (LP-L). Results: Elevations in usCRP levels in the LP-L were observed in the entire group and in anovulatory cycles (1.9±1.1 mg/L in FP to 2.5±1.8mg/L in LP-L; p<0.0001). Increases in estrone, estradiol, free and bioavailable estradiol, testosterone, usCRP and 2OHE levels were observed in LP-L compared with FP (p<0.01), with a borderline elevation in IFG-I levels (p = 0.06). Conclusions: We report an elevation of usCRP and 2OHE levels during the luteal phase in healthy adolescents. Elevations of this inflammatory marker in anovulatory adolescents without an increase in 2OHE may play a role in metabolic risks associated with chronic anovulation.
机译：介绍：在肺癌期间的成年女性中据报道炎症标志物的变化，但在青春期期间观察到这些发现是否未知。在年轻女性的肺癌期间，我们假设较高的超敏C反应蛋白（USCRP）和低羟基苯（2Ohe）水平，具有心脏保护作用的雌激素代谢物。目的：评估月经周期期间的USCRP水平，并在青少年中确定其与2OHE和16Alpha-羟乙酮（16Ohe）的关联。方法：在滤泡相（FP）中的一个月经周期（FP）和肺癌相似期（LP-L）期间研究了健康的止血青少年（n = 37）。结果：在整个组中观察到LP-L中的USCRP水平的升高，并在液相识中，在FP中的防护循环中（1.9±1.1mg / L; p <0.0001）。在LP-L中，与FP（P <0.01）相比，在LP-L中观察到雌激素，雌二醇，自由和生物利用雌二醇，睾酮，USCRP和2OHE水平，IFG-I水平的边界升高（P = 0.06）。结论：在健康青少年的氯化术期间报告了USCRP和2OHE水平的升高。在没有2Ohe的不增加而不增加的内炎青少年中这种炎症标志物的升高可能在与慢性无氧疏动相关的代谢风险中起作用。

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