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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Should insulin resistance be screened in lean hirsute women
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Should insulin resistance be screened in lean hirsute women

机译：应该在瘦血症女性中筛查胰岛素抵抗力

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摘要

The role of insulin resistance (IR) is well-documented in obese women with polycystic ovary syndrome (PCOS). Controversies exist concerning the presence of IR in idiopathic hirsutism (IH) or if it is a manifestation of high body mass index (BMI). We aimed to investigate the presence/ absence of IR in lean hirsute women. One-hundred fifty-one lean women with hirsutism [96 PCOS (group 1) and 55 IH (group 2)] and 58 age-and BMI-matched healthy controls (group 3) were recruited in the study (mean age 25.21 + 6.1 versus 26.26 ± 4.6years; BMI 21.79 ± 1.7 versus 22.02± 2.2 kg/m2, respectively). Significantly higher insulin and HOMA-IR, and significantly lower fasting glucose insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI), reciprocal insulin, and Raynaud index were detected in groups 1 and 2 than in group 3 (p < 0.05). These IR indices were similar between groups 1 and 2. The number of patients with IR (HOMA-IR > 2, FGIR < 7.2, or QUICKI < 0.357) was significantly higher in groups 1 and 2 than in group 3, but was similar between groups 1 and 2. A higher frequency of IR occurs in lean hirsute women regardless of they having PCOS or IH. IR may contribute to aetiopathogenesis of IH, or may cause some metabolic abnormalities in these patients.
机译：胰岛素抵抗（IR）的作用在具有多囊卵巢综合征（PCOS）的肥胖妇女中齐全。存在关于发作性Hirsutism（IH）的IR的存在的争议，或者是高体重指数（BMI）的表现。我们的目标是调查瘦士满足女性中的IR的存在/不存在。在研究中招募了一百五十一名贫民（第96个PCOS（第1组）和55 IH（第2组）和58岁和BMI匹配的健康对照（第3组）（平均年龄25.21 + 6.1与26.26±4.6秒; BMI 21.79±1.7分别与22.02±2.2千克/ m2）。在第1组和2组中，在第1组和2组中检测到显着更高的胰岛素和HOMA-IR，显着降低空腹葡萄糖胰岛素比（FGIR），定量胰岛素敏感性检查指数（Quicki），互惠胰岛素和雷诺鲁氏症（P <0.05） 。这些IR指数在第1组和2组之间类似于IR（HOMA-IR> 2，FGIR <7.2或Quicki <0.357）的患者的数量比第3组和2组显着高，但之间相似1和2.较高频率的IR发生在瘦士满足女性中，无论他们都有PCOS或IH。 IR可能有助于IH的AetiopoH发生，或可能导致这些患者的一些代谢异常。

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