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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Successive and cyclic oral contraceptive pill pretreatment improves IVF/ICSI outcomes of PCOS patients and ameliorates hyperandrogenism and antral follicle excess
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Successive and cyclic oral contraceptive pill pretreatment improves IVF/ICSI outcomes of PCOS patients and ameliorates hyperandrogenism and antral follicle excess

机译：连续和循环口腔避孕药预处理改善了PCOS患者的IVF / ICSI结果，改善了高衰变和嗜睡卵泡过量

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摘要

Objectives: To evaluate different oral contraceptive pill (OCP) pretreatment associated differential in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) outcomes of polycystic ovary syndrome (PCOS) patients and explore enhanced hormonal balance induced by the pretreatment. Methods: This retrospective study included 500 PCOS women and 565 normal ovulating counterparts undergoing IVF/ICSI. The PCOS patients were divided into three groups based on the OCP pretreatment regimens: non-OCP (without OCP pretreatment), unsuccessive OCP (the period of successive pretreatment <2 months) and successive OCP (the period of successive pretreatment >3 months) groups. Comprehensive hormonal and ultra-sonographic assessments were performed before/after IVF pretreatment. Confounding factors affecting pregnancy outcomes were analyzed with logistic regression. Results: PCOS patients with significant endocrine disorders had reduced implantation and pregnancy rates and increased miscarriage rate. Successive, not unsuccessive OCP pretreatment, significantly improved the implantation and pregnancy rates, and reduced the incidence of monotocous small-for-gestational age infants, which was accompanied by remarkably decreased hyperandrogenism and antral follicles. Conclusion: PCOS is an independent risk factor for poor IVF outcome. Successive, not unsuccessive, OCP cyclical pretreatment could improve pregnancy outcome of PCOS patients, associated with reduction of hyperandrogenism and antral follicle excess.
机译：目的：为了评估不同口服避孕药（OCP）预处理相关的差异差异施用（IVF）/ issi）的多囊卵巢综合征（PCOS）患者的结果，并探讨预处理引起的增强荷尔蒙平衡。方法：该回顾性研究包括500名PCOS女性和565个正常排卵对应物，正在进行IVF / ICSI。基于OCP预处理方案的PCOS患者分为三组：非OCP（没有OCP预处理），不成功的OCP（连续预处理<2个月的时间）和连续的OCP（连续预处理时期> 3个月）组。在IVF预处理之前/之后进行全面的激素和超声超声检查评估。利用逻辑回归分析了影响妊娠结果的混杂因素。结果：具有重要内分泌疾病的PCOS患者具有降低的植入和妊娠率，并增加流产率。连续，而不是不成功的OCP预处理，显着提高了植入和妊娠率，并减少了单不管小胎龄婴儿的发病率，其伴有了高衰变和嗜睡卵泡的显着降低。结论：PCOS是IVF结果不佳的独立危险因素。连续，不是不成功的，OCP循环预处理可以改善PCOS患者的妊娠结束，与减少高衰老症和嗜睡卵泡过量相关。

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