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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome
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Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome

机译：脂联素和瘦素在超重/肥胖和瘦妇女中具有多囊卵巢综合征

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Aim: The objective of this study was to evaluate the adiponectin and leptin levels in overweight/obese and lean women with polycystic ovary syndrome (PCOS). Design: This was a retrospective study. Patients: Of the 422 studied patients, 224 women with PCOS and 198 women without PCOS were evaluated. Main outcome measure(s): Insulin resistance and the metabolic components were assessed. The adiponectin and leptin levels were also evaluated. Results: Adiponectin was negatively correlated with insulin resistance, body mass index (BMI), and total testosterone, triglyceride, and low-density lipoprotein (LDL) levels; conversely, leptin reversed the aforementioned reaction and was negatively correlated with adiponectin levels. The adiponectin to leptin ratios were significantly lower in PCOS women than in those without PCOS. Compared to women with non-PCOS, overweight/obese women with PCOS had lower serum adiponectin levels than women without PCOS, which was not the case for lean women. Conversely, lean women with PCOS had higher serum leptin levels than those without PCOS, which was not the case for overweight/obese women.Conclusions: Adipose tissue might play an important role in the metabolic complications in women with PCOS. To study the impact of obesity biomarkers in women with PCOS, overweight/obese and lean women should be considered separately.
机译：目的：本研究的目的是评估超重/肥胖和瘦妇女的脂联素和瘦素水平，具有多囊卵巢综合征（PCOS）。设计：这是一个回顾性研究。患者：422例研究患者，评估了224名没有PCOS的PCOS和198名女性的女性。主要结果测量：评估胰岛素抵抗和代谢组分。还评估了脂联素和瘦素水平。结果：脂联素与胰岛素抵抗，体重指数（BMI）和总睾酮，甘油三酯和低密度脂蛋白（LDL）水平负相关;相反，瘦素逆转了上述反应，与脂联素水平负相关。 PCOS女性的脂肪蛋白比瘦素比率显着低于没有PCOS的妇女。与非PCOS的女性相比，具有PCOS的超重/肥胖妇女的血清脂联素水平比没有PCOS的女性，这不是精益女性的妇女。相反，瘦性的PCOS患有更高的血清瘦素水平，而不是没有PCOS的血清瘦素水平，这不是超重/肥胖女性的情况。结论：脂肪组织可能在PCOS女性的代谢并发症中发挥重要作用。为研究肥胖生物标志物在PCOS中的妇女的影响，超重/肥胖和精益妇女应分开考虑。

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