• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The evaluation of endometrial sulfate glycosaminoglycans in women with polycystic ovary syndrome
【24h】

The evaluation of endometrial sulfate glycosaminoglycans in women with polycystic ovary syndrome

机译：多囊卵巢综合征妇女子宫内膜硫酸盐糖胺聚糖的评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to quantify the sulfated glycosaminoglycans in the endometria of women with polycystic ovary syndrome (PCOS). Of the 18 patients recruited for this study, 10 patients with PCOS comprised the PCOS group (PCOSG), and eight patients with regular and ovulatory menstrual cycles comprised the control group (CG). The clinical, biochemical, morphological and endometrial data from both groups were analyzed. Biopsies were performed during the proliferative phase of the menstrual cycle for the CG and during the persistent proliferative phase for the PCOSG (all women were amenorrheic). In the PCOSG, there was a significant increase in the endometrial concentration levels of heparan sulfate (p = 0.03), but no difference in the concentrations of chondroitin sulfate was determined between the two groups (p = 0.77). Period of time without menstruation (p = 0.001) and body mass index (BMI) (p = 0.04) correlated directly and positively with heparan sulfate concentration. There was no association between heparan sulfate levels and basal insulin values (p = 0.08). High levels of endometrial heparan sulfate in women with PCOS indicate an interference with maternal-fetal recognition, which contributes to infertility; thus, endometrial heparan sulfate may be a predictive marker of future neoplasia risk.
机译：本研究的目的是通过多囊卵巢综合征（PCOS）量化患有妇女的子宫内膜中的硫酸化糖酰胺聚糖。在本研究招募的18名患者中，10例PCOS患者包含PCOS组（PCOSG），8名患有的患有对照组（CG）的定期和排卵月经循环的患者。分析了两组的临床，生化，形态学和子宫内膜数据。在CG的月经循环的增殖阶段和PCOSG的持续增殖相期间进行活组织检查（所有女性是闭经的）。在PCOSG中，子宫内膜浓度水平的硫酸乙酰肝素浓度水平显着增加（p = 0.03），但在两组之间测定硫酸软骨素浓度的差异（P = 0.77）。没有月经的时间（p = 0.001）和体重指数（Bmi）（p = 0.04）直接且正质量指数（p = 0.04）与硫酸乙酰肝素浓度相比。硫酸乙酰肝素水平与基底胰岛素值之间没有关联（p = 0.08）。 PCOS中女性中硫酸亚硫酸盐的高水平子宫内膜硫酸钠表明患有母体识别的干扰，这有助于不孕;因此，子宫内膜硫酸乙酰肝素可能是未来肿瘤风险的预测标记。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号