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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Alpha lipoic acid in obstetrics and gynecology
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Alpha lipoic acid in obstetrics and gynecology

机译：alpha硫辛酸在妇产科中

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摘要

Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative decarboxylation of pyruvate and a-ketoglutarate. In this review, we analyzed the action of ALA in gynecology and obstetrics focusing in particular on neuropathic pain and antioxidant and anti-inflammatory action. A comprehensive literature search was performed in PubMed and Cochrane Library for retrieving articles in English language on the antioxidant and anti-inflammatory effects of ALA in gynecological and obstetrical conditions. ALA reduces oxidative stress and insulin resistance in women with polycystic ovary syndrome (PCOS). The association of N-acetyl cysteine (NAC), alpha-lipoic acid (ALA), and bromelain (Br) is used for prevention and treatment of endometriosis. In association with omega-3 polyunsaturated fatty acids (n-3 PUFAs) with amitriptyline is used for treatment of vestibulodynia/painful bladder syndrome (VBD/PBS). A promising area of research is ALA supplementation in patients with threatened miscarriage to improve the subchorionic hematoma resorption. Furthermore, ALA could be used in prevention of diabetic embryopathy and premature rupture of fetal membranes induced by infla-mation. In conclusion, ALA can be safely used for treatment of neuropatic pain and as a dietary support during pregnancy.
机译：α-硫辛酸（ALA）是由植物和动物合成的天然抗氧化剂，被鉴定为丙酮酸和酮戊酸的氧化脱羧剂的催化剂。在本综述中，我们分析了ALA在妇科和产科的作用，特别是对神经性疼痛和抗氧化剂和抗炎作用。在PubMed和Cochrane库中进行了一个综合文献搜索，用于检索英语文章，用于妇科和产科病症中ALA的抗氧化剂和抗炎作用。 ALA减少了具有多囊卵巢综合征（PCOS）的妇女氧化应激和胰岛素抗性。 N-乙酰半胱氨酸（NAC），α-硫辛酸（ALA）和溴（BR）的缔合用于预防和治疗子宫内膜异位症。与ω-3多不饱和脂肪酸（N-3 PUFA）与Amitriptyle相关联用于治疗前胃痛/痛苦的膀胱综合征（VBD / PBS）。有希望的研究领域是患有威胁流产的患者的ALA补充，以改善亚替代血肿吸收。此外，ALA可用于预防令人生气诱导的胎儿胚胎病变和过早破裂。总之，ALA可以安全地用于治疗神经疼痛和妊娠期间的膳食载体。

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