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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The effects of letrozole on women with endometriosis undergoing ovarian stimulation for in vitro fertilization
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The effects of letrozole on women with endometriosis undergoing ovarian stimulation for in vitro fertilization

机译：Letrozole对患有子宫内膜异位症的妇女体外刺激的影响

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摘要

This study aimed to analyze the effects of a new protocol with letrozole on the outcomes of in vitro fertilization (IVF) cycles in women with endometriosis. This retrospective cohort study was conducted for women diagnosed with endometriosis undergoing IVF from an infertility clinic. A new protocol, combination therapy with letrozole and gonadotropin, was used from August 2016 to January 2018 ('protocol 1', n = 38). From March 2014 to July 2016, conventional IVF with gonadotropin was administered ('protocol 2', n = 26). Age and ovarian reserve were comparable between the two groups. The patients who received protocol 1 resulted in a significantly lower peak estradiol level in IVF compared with those received protocol 2 (722 +/- 1076 pg/mL versus 2168 +/- 1521 pg/mL, p < .001). The length of stimulation, the total dose of gonadotropin, number of oocytes retrieved, fertilization rates, and number of embryos obtained were similar between the two groups. The mean percentage of mature oocytes was lower (69.9 +/- 23.7% versus 80.2 +/- 21.0%, p = .029) in patients with protocol 1. While maintaining low estrogen levels, the combination therapy with letrozole and gonadotropin produce similar oocyte and embryo yield to the conventional IVF protocol in women with endometriosis.
机译：本研究旨在分析新方案与Letrozole对具有子宫内膜异位症妇女体外施肥（IVF）循环的结果的影响。该回顾性队列研究是针对被诊断患有来自不孕症诊所的子宫内膜异位症的女性进行的研究。从2016年8月至2018年1月（“议定书1”，N = 38）使用了一种新的新方案，使用Letrozole和Gonadotropin的组合治疗。从2014年3月至2016年7月，常规IVF与促性腺激素进行管理（'协议2'，n = 26）。年龄和卵巢储备在两组之间相当。接受方案1的患者与接受的方案2（722 +/- 1076 pg / ml与2168 +/- 1521 pg / ml，p <.001）相比，IVF中的峰值雌二醇水平显着降低了IVF的峰雌二醇水平。刺激的长度，促性腺激素的总剂量，检索到的卵母细胞的数量，施肥率和所得胚胎的数量在两组之间相似。成熟卵母细胞的平均百分比较低（69.9 +/- 23.7％，与方案患者的80.2 +/- 21.0％，p = .029），同时保持低雌激素水平，使Letrozole和促性腺激素的联合治疗产生类似的卵母细胞胚胎产量与子宫内膜异位症的常规IVF方案。

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