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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Absence of correlation between follicular fluid volume and follicular granulocyte colony-stimulating factor, a predictor of embryo implantation and successful delivery
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Absence of correlation between follicular fluid volume and follicular granulocyte colony-stimulating factor, a predictor of embryo implantation and successful delivery

机译：没有卵泡液体体积和卵泡粒细胞菌落刺激因子的相关性，胚胎植入的预测因子和成功递送

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摘要

Follicular granulocyte colony-stimulating factor (G-CSF) is a documented marker of embryo implantation potential. The primary objective was to determine whether follicular G-CSF levels correlate with follicular fluid volume. The secondary objectives were to assess whether follicular G-CSF is associated with oocyte maturity at the time of harvest and with delivery rate after fresh or frozen embryo transfer. Thirty-two patients undergoing intracytoplasmic sperm injection (ICSI) cycles were recruited (Centre de Procreation Medicalement Assistee (CPMA), University of Liege, Belgium). A total of 211 follicular fluid (FF) samples were individually collected at the time of oocyte harvest. FF volume was recorded, and G-CSF concentration was assessed by ELISA. The embryos were individually cultured in vitro. Their implantation and live birth rates were recorded after fresh and frozen embryo transfers. The follicular fluid volume did not correlate with the follicular G-CSF concentration. There were no differences in follicular G-CSF levels between mature and immature oocytes. The probability of successful implantation and delivery was increased for embryos with FF containing a high G-CSF concentration. There was a trend toward lower follicular G-CSF levels in cases of miscarriage. Therefore, follicular fluid volume cannot be a substitute for follicular G-CSF as a marker of embryo implantation ability.
机译：卵泡粒细胞菌落刺激因子（G-CSF）是胚胎植入势的记录标记。主要目的是确定彩色G-CSF水平是否与滤泡液容量相关。次要目的是评估滤饼G-CSF是否与收获时的卵母细胞成熟与新鲜或冷冻胚胎转移后的递送速率相关。招募了患有血晶杆术治疗（ICSI）循环的三十二名患者（Center de Procreation医疗Assistee（CPMA），列尔大学，比利时）。在卵母细胞收获时，共收集总共211个卵泡液（FF）样品。记录FF体积，ELISA评估G-CSF浓度。胚胎在体外单独培养。在新鲜和冷冻的胚胎转移后，记录了它们的植入和活产率。滤泡流体体积与滤泡G-CSF浓度无关。成熟和未成熟卵母细胞之间的卵泡G-CSF水平没有差异。对于含有高G-CSF浓度的FF的胚胎，增加了成功植入和递送的可能性。在流产的情况下，较低的滤泡G-CSF水平存在趋势。因此，滤泡流体体积不能是卵泡G-CSF作为胚胎注入能力的标志物的替代品。

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