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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Levothyroxine supplementation on assisted reproduction technology (ART) outcomes in women with subtle hypothyroidism: a retrospective study
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Levothyroxine supplementation on assisted reproduction technology (ART) outcomes in women with subtle hypothyroidism: a retrospective study

机译：在 辅助生殖 技术 （ ART） 甲状腺素 补充 成果 在 妇女 微妙的 甲状腺功能减退症 ： 一项回顾性研究

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The need for treating subclinical hypothyroidism (SCH) in women undergoing assisted reproduction technology (ART) is under debate. Moreover, it is known that controlled ovarian hyperstimulation (COH) protocols may impair the thyroidal axis. Therefore, we evaluated if levothyroxine (L-T4) supplementation in SCH women before undergoing ART positively affects the main reproductive outcomes. We retrospectively analyzed in vitro fertilization (IVF) data of 4147 women submitted to 6545 cycles in a tertiary care IVF Center (January 2009-December 2014). L-T4 (1.4-2.0 mcg/kg) treatment was offered to all women with a pre-cycle TSH 2.5 mIU/L before starting COH and main ART outcomes were compared in euthyroid and L-T4-treated women undergoing ART. Among 4147 women, 1074 (26%) were affected by SCH and were treated with L-T4 before COH was started. No statistically significant differences among L-T4-treated and euthyroid women group were observed regarding pregnancy rate, respectively, per cycle (27.67% vs 26.37%; p = .314) and per embryo transfer (30.13% vs 29.17%; p = .489), live birth rate, respectively, per cycle (21.58% vs 20.38%; p = .304) and per embryo transfer (23.49 vs 22.54%; p = .449) and the rest of primary and secondary efficacy endpoints. Early L-T4 treatment for infertile women with a subtle thyroid dysfunction may mitigate and protect from the negative effects of SCH in the setting of ART, and may preventively overcome also the negative impact of COH on thyroidal axis.
机译：需要治疗辅助生殖技术（艺术）的妇女亚临床甲状腺功能减退症（SCH）的需求在辩论下。此外，已知受控卵巢过度刺激（COH）方案可能损害甲状腺轴。因此，我们评估了在接受艺术之前的Sch女性的左甲苯胺（L-T4），积极影响主要生殖结果。我们回顾性地分析了4147名妇女的体外施肥（IVF）数据，提交至第三级护理IVF中心（2009年1月至2014年12月）。 L-T4（1.4-2.0 mcg / kg）治疗提供给所有患有前周期Tsh＆gt的妇女; 2.5 miu / l在开始核心之前，在Euthyroid和L-T4治疗的女性接受艺术中比较了主要艺术成果。在4147名女性中，1074（26％）受SCH的影响，并在COH开始之前用L-T4治疗。每周期分别没有分别观察到L-T4治疗和治疗术后妇女组的统计学显着差异（27.67％vs 26.37％; p = .314）和每胚胎转移（30.13％与29.17％; p =。 489），每周期分别出生率（21.58％vs 20.38％; p = .304）和胚胎转移（23.49与22.54％; p = .449）和其余的初级和次级疗效终点。早期的L-T4治疗适用于细微甲状腺功能障碍的不孕症，可以减轻和保护SCH在艺术环境中的负面影响，并且可以预防性地克服COH对甲状腺轴上的负面影响。

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