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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Brain-derived neurotrophic factor (BDNF) plasma concentration in patients diagnosed with premature ovarian insufficiency (POI)
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Brain-derived neurotrophic factor (BDNF) plasma concentration in patients diagnosed with premature ovarian insufficiency (POI)

机译：患者诊断出过早卵巢不足（POI）的患者中脑衍生的神经营养因子（BDNF）血浆浓度

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Premature ovarian insufficiency (POI) is defined as a cessation of function of ovaries in women younger than 40 years old. Brain-derived neurotrophic factor (BDNF) is a protein critically involved in neuronal growth and metabolism. BDNF also has been shown to be important regulator of oocyte maturation. Recent data show that BDNF can be potentially involved in POI pathology. The aim of the study was to assess the BDNF plasma concentrations in patients diagnosed with idiopathic POI. 23 women diagnosed with POI (age 31 +/- 7 years) and 18 (age 31 W +/- 3) controls were included to the study, matched according to age and body mass index. The BDNF concentrations were measured using competitive enzyme-linked immunosorbent assay (ELISA). Hormonal and metabolic parameters were measured in all individuals, in controls in late follicular phase. The POI group demonstrated lower mean plasma concentrations of BDNF (429.25 +/- 65.52 pg/ml) in comparison to healthy controls (479.75 +/- 34.75 pg/ml, p = 0.0345). The BDNF plasma concentration correlated negatively (R = -0.79, p0.001) with number of months since last menstrual period. There was a positive correlation between BDNF and progesterone in controls. In conclusion, POI patients show significantly lower BDNF plasma concentration and it correlates with the duration of amenorrhea. This observation brings important potential insights to the pathology of POI.
机译：过早的卵巢不足（POI）被定义为卵巢卵巢功能的停止，女性患者小于40岁。脑衍生的神经营养因子（BDNF）是批判性涉及神经元生长和代谢的蛋白质。 BDNF也已被证明是卵母细胞成熟的重要调节剂。最近的数据显示BDNF可能涉及POI病理学。该研究的目的是评估患有特发性POI的患者的BDNF血浆浓度。在研究中纳入了23名患有POI（31岁+/- 7岁）的女性和18名（31％+/- 3）对照，根据年龄和体重指数匹配。使用竞争性酶联免疫吸附试验（ELISA）测量BDNF浓度。在晚期卵泡相的对照中，在所有个体中测量荷尔蒙和代谢参数。与健康对照（479.75 +/- 34.75 pg / ml，p = 0.0345）相比，POI组展示了BDNF（429.25 +/- 65.52pg / ml）的较低平均血浆浓度（429.25 +/- 65.52 pg / ml）。 BDNF等离子体浓度与上半次月经期间以来的月份负相关（R = -0.79，P <0.001）。 BDNF与对照中的黄体酮之间存在正相关性。总之，POI患者显示出明显降低的BDNF血浆浓度，与闭经的持续时间相关。这种观察结果为POI的病理带来了重要的潜在见解。

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