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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Association of serum leptin with bone mineral density in postmenopausal osteoporotic females
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Association of serum leptin with bone mineral density in postmenopausal osteoporotic females

机译：绝经后骨质疏松术女性血清瘦素与骨密度的关联

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Objective: Present study was designed to find out whether leptin is a predictor of bone mass density (BMD) in premenopausal women (PMW) and postmenopausal osteoporotic women (PMOPW) or it has no association with BMD.Methods: One hundred and ninety two women (98 PMOPW and 94 PMW) were recruited for this study. The control group was BMI matched with osteoporotic subjects. BMD assessment was done on calcaneus by peripheral ultrasound bone densitometry and T scores were determined. Serum leptin levels were measured by enzyme-linked immunosorbent assay (ELISA).Results: Serum leptin and BMD values were significantly different in both groups (leptin, 18.568.65ng/ml versus 21.649.80ng/ml, p=0.02) and (BMD, -0.700.19 versus -3.170.59, p=0.000), respectively. In PMOPW serum leptin and BMD were considerably correlated with weight (lep, r=0.53, p=<0.001; BMD, r=-0.21, p=0.02), BMI (lep, r=0.52, p =<0.001; BMD, r=-0.27, p=0.005), waist circumference (lep, r=0.61, p=<0.001; BMD, r=0.18, p=0.04), hip circumference (lep, r=0.58, p=<0.001).Multivariate linear stepwise regression analysis showed that weight and BMI in PMW and PMOPW were independent predictors of BMD. Serum leptin level was not found to be the predictor of BMD in both groups.Conclusion: The present results indicate that body weight and BMI have an impact on BMD while serum leptin is not associated with BMD in PMW and PMOPW.
机译：目的：目前的研究旨在了解瘦素是否是骨质妇女（PMW）和绝经后骨质疏松妇女（PMOPW）的骨质密度（BMD）的预测因子，或者与BMD的关系。方法：一百九十名女性（98 PMOPW和94 PMW）被招募了这项研究。对照组是与骨质疏松科目相匹配的BMI。 BMD评估通过外周超声骨密度测定，并测定T分数。通过酶联免疫吸附测定（ELISA）测量血清瘦素水平，-0.700.19与-3.170.59，p = 0.000）。在PMOPW血清瘦素和BMD与重量（LEP，R = 0.53，P = <0.001，BMD，R = -0.21，P = 0.02），BMI（LEP，R = 0.52，P = <0.001; BMD， r = -0.27，p = 0.005），腰围（LEP，r = 0.61，p = <0.001; BMD，r = 0.18，P = 0.04），髋周（LEP，r = 0.58，p = <0.001）。多变量线性逐步回归分析显示PMW和PMOPW中的重量和BMI是BMD的独立预测因子。未发现血清瘦素水平是BMD在两组中的预测因子。结论：本结果表明体重和BMI对BMD产生影响，而血清瘦素与PMW和PMOPW中的BMD无关。

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