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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC)
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Body composition and psychological improvement in healthy premenopausal women assuming the oral contraceptive containing micronized estradiol (E2) and nomegestrol acetate (NOMAC)

机译：含有微粉化雌二醇（E2）和Nomegestrol乙酸盐（Nomac）的口腔避孕药（Nomac），身体成分和心理改善健康前辈妇女

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This observational study was conducted in healthy premenopausal women, who presented themselves for contraceptive advice at the outpatient Family Planning Clinics of the Department of Obstetrics and Gynecology of the University of Cagliari, Hospital-University of Cagliari (Italy). After a screening period of three menstrual cycles, 48 women without contraindications to estroprogestin contraceptives (OCs) were included in the study. The primary purposes of the study were to evaluate whether a 12-month-treatment with the combined OC containing micronized estradiol (1.5mg, E2) plus nomegestrol acetate (2.5mg, NOMAC) (E2/NOMAC) interfere on anthropometric indices (AI), body composition (BC) and psychological status (PS). In subjects with dysmenorrhea (#36), its intensity was evaluated using the visuo analogic scale (VAS), both before and during the 12-month-treatment with E2/NOMAC. E2/NOMAC did not modify neither AI nor BC in the 40 subjects who concluded the study. The PS and the VAS of dysmenorrhea were significantly (p<0.0001) improved from the first cycle of treatment and throughout the E2/NOMAC treatment in comparison with basal values. The study suggests that E2/NOMAC is devoid of negative effects on AI and BC, with additional benefits on PS and dysmenorrhea.
机译：该观察研究是在健康的前进妇女中进行的，为Cagliari大学（意大利Cagliari大学）妇产科的门诊和妇科的门诊计划诊所提供避孕咨询。在筛选期的3个月经周期后，48名没有禁忌症的雌性嗜雌激素避孕药（OCS）的妇女被纳入该研究。该研究的主要目的是评估与含有微粉化雌二醇（1.5mg，E2）加上Nomegestrol乙酸酯（2.5mg，Nomac）（E2 / NOMAc）干扰人类索引（AI）的组合治疗吗？ ，身体成分（BC）和心理状态（PS）。在患有痛经（＃36）的受试者中，使用E2 / NOMAC的12个月治疗之前和期间，使用Visuo模拟量表（VAS）评估其强度。 E2 / NOMAC在结束这项研究的40个科目中没有修改AI和BC。从第一个治疗循环和整个E2 / NOMAC治疗的患者和痛经的PS和VAS的显着（p <0.0001）改善，与基础值相比。该研究表明，E2 / NOMAC对AI和BC没有负面影响，对PS和痛经具有额外的益处。

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