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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Preptin in women with polycystic ovary syndrome
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Preptin in women with polycystic ovary syndrome

机译：Preptin在妇女患有多囊卵巢综合征

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Introduction: Polycystic ovary syndrome (PCOS) patients, frequently develop metabolic complications, such as insulin resistance (IR), impaired carbohydrate metabolism, dyslipidemia, obesity. Among the new markers responsible for metabolic disorders, preptin seems to be of great significance.Material: One hundred and thirty-four women aged 17-45 were enrolled. PCOS was diagnosed in 73 women on the basis of ESHRE-ASRM criteria. Non-PCOS group consisted of 61 women with regular menstruation matched for nutritional status.Methods: All women underwent anamnesis, physical examination, anthropometric measurements, the abdominal ultrasound examination, and dual energy X-ray absorptiometry (DXA). Serum adropin levels were determined by ELISA. Biochemical and hormonal (testosterone, androstenedione, LH, FSH, estradiol) measurements were also performed. Insulin resistance indices (HOMA, QUICKI, Matsuda) and free androgen index (FAI) were calculated with the test results according to the standard formula. For all comparisons, statistical significance was defined by p.05.Results: Serum preptin levels were significantly higher in the PCOS group. No significant correlations between preptin level and metabolic and hormonal markers were observed. The logistic regression analysis demonstrated that serum preptin level was an independent factor differentiating the two groups.Conclusions: Serum preptin levels were significantly higher in women with PCOS compared with controls. This peptide might be an independent predictor of PCOS in the future.
机译：介绍：多囊卵巢综合征（PCOS）患者，经常发育代谢并发症，如胰岛素抵抗（IR），碳水化合物代谢受损，血脂血症，肥胖症。在负责代谢障碍的新标志中，PREPTIN似乎具有重要意义.17-45年龄17-45岁的19岁及三十四名妇女。基于ESHRE-ASRM标准，PCOS被诊断为73名妇女。非PCOS组由61名患有常规月经的妇女进行营养状况。方法：所有妇女都接受了厌氧，物理检查，人类测量测量，腹部超声检查和双能X射线吸收术（DXA）。通过ELISA测定血清Adropin水平。还进行了生物化学和激素（睾酮，雄甾酮，LH，FSH，雌二醇）测量。根据标准配方用测试结果计算胰岛素抵抗指数（HOMA，Quicki，Matsuda）和自由雄激素指数（FAI）。对于所有比较，P.05的统计学意义。结果：PCOS组中血清PREPTIN水平显着高。观察到PREPTIN水平与代谢和荷尔蒙标记物之间没有显着相关性。逻辑回归分析表明，血清PREPTIN水平是区分两组的独立因素。结论：PCOS与对照相比，PCOS的女性血清PREPTIN水平显着高。该肽可能是未来PCOS的独立预测因子。

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