• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The impact of autoimmunity-related early ovarian aging on ICSI cycle outcome
【24h】

The impact of autoimmunity-related early ovarian aging on ICSI cycle outcome

机译：自身免疫相关早期老龄化对ICSI周期结果的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to investigate the impact of anti-thyroid peroxidase antibodies (Anti-TPO) on the in vitro fertilization and embryo transfer (IVF-ET) outcome in women with poor ovarian reserve but normal thyrotropin levels. A total of 300 patients with poor ovarian reserve undergoing ICSI cycle from April 2015 to December 2017 were analyzed retrospectively. Subjects were divided into two groups: Group 1: Women with early ovarian aging, Group 2: Women with age related poor ovarian reserve. All subjects underwent anti-thyroid peroxidase antibody (anti-TPO) analysis. The impacts of age and anti-TPO positivity on cycle outcome were assessed. There were no significant differences in basal FSH, basal AMH levels, and antral follicle count between the two main groups. Groups were also comparable in terms of the duration of ovarian stimulation, peak estradiol level, starting gonadotropin dose, total gonadotropin dose, and number of oocytes retrieved. Clinical pregnancy and cycle cancelation rates were significantly higher in group with age-related poor ovarian reserve. While autoimmune thyroid disease rate was significantly higher in group with early ovarian aging. Anti-TPO positivity was a risk factor for poor cycle outcome [RR: 2.8 (95% Cl: 1.2-6.3)]. Early ovarian aging may be associated with poorer cycle outcome compared to group with age-related poor ovarian reserve. This difference may be associated with high rate of autoimmunity which led to the impaired endometrial receptivity.
机译：本研究的目的是探讨抗甲状腺过氧化物酶抗体（抗TPO）对卵巢储备不良妇女的体外施肥和胚胎转移（IVF-ET）的影响，但正常的甲状腺水平。回顾性从2015年4月到2017年4月到2017年4月，共有300名卵巢储备患者，从2017年4月到2017年12月进行了分析。受试者分为两组：第1组：患有早期卵巢衰老的妇女，第2组：有年龄相关的卵巢储备的妇女。所有受试者接受抗甲状腺过氧化物酶抗体（抗TPO）分析。评估年龄和抗TPO积极性对循环结果的影响。基础FSH，基础AMH水平和两种主要组之间的嗜睡卵泡计数没有显着差异。在卵巢刺激的持续时间，峰雌二醇水平，起始促性腺激素剂量，总促性腺激素剂量和检索的卵母细胞数量，组也是相当的。与年龄相关的可怜的卵巢储备，临床怀孕和循环取消率显着高。虽然具有早期卵巢衰老的组体中自身免疫性甲状腺疾病率明显高。抗TPO阳性是较差的循环结果的危险因素[RR：2.8（95％Cl：1.2-6.3）]。与年龄相关的可怜的卵巢储备的组相比，早期卵巢老化可能与较差的周期结果相关联。这种差异可以与高度的自身免疫率相关联，这导致了子宫内膜受损。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号