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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The effects of chronic oxytocin administration on body weight and food intake in DHT-induced PCOS model rats
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The effects of chronic oxytocin administration on body weight and food intake in DHT-induced PCOS model rats

机译：慢性催产素给药对DHT诱导的PCOS模型大鼠体重和食物摄入量的影响

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摘要

Polycystic ovary syndrome (PCOS) is commonly associated with metabolic disorders, which are exacerbated by obesity. Recent studies have revealed that oxytocin contributes to metabolic, appetite, and body weight regulation. In the present study, we evaluated the effects of chronic administration of oxytocin on body weight, food intake, and fat mass in a dihydrotestosterone-induced rat model of PCOS. Body weight, body weight change, and relative cumulative food intake were significantly lower in the oxytocin-treated PCOS rats than in the vehicle-treated control PCOS rats. Similarly, visceral adipocyte size was significantly smaller in the oxytocin-treated PCOS rats than in the vehicle-treated control PCOS rats. On the other hand, the numbers of cystic follicles in the ovary did not differ between the two groups. The chronic administration of oxytocin did not affect the rats' serum aspartate aminotransferase, alanine aminotransferase, or lactate dehydrogenase levels, indicating that it does not have adverse effects on hepatic function. These findings suggest that oxytocin could be a candidate drug for preventing the onset of obesity-related metabolic disorders in PCOS patients.
机译：多囊卵巢综合征（PCOS）通常与代谢紊乱有关，其通过肥胖而加剧。最近的研究表明，催产素有助于代谢，食欲和体重调节。在本研究中，我们评估了催产素慢性施用对二氢甾酮诱导的PCOS大鼠大鼠模型中体重，食物摄入和脂肪物质的影响。在催产素治疗的PCOS大鼠中，体重，体重变化和相对累积的食物摄入量显着降低于载体处理的对照PCOS大鼠。类似地，催产素治疗的PCOS大鼠的内脏脂肪细胞尺寸明显小于车辆处理的对照PCOS大鼠。另一方面，卵巢中囊性卵泡的数量在两组之间没有差异。催产素的慢性施用不影响大鼠血清天冬氨酸氨基转移酶，丙氨酸氨基转移酶或乳酸脱氢酶水平，表明它对肝功能没有不利影响。这些发现表明，催产素可以是用于预防PCOS患者的肥胖相关的代谢障碍的候选药物。

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