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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The effects of letrozole and clomiphene citrate on ligands expression of Wnt3, Wnt7a, and Wnt8b in proliferative endometrium of women with Polycystic ovarian syndrome
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The effects of letrozole and clomiphene citrate on ligands expression of Wnt3, Wnt7a, and Wnt8b in proliferative endometrium of women with Polycystic ovarian syndrome

机译：Letrozole和Clomiphenhe柠檬酸对多囊卵巢综合征的妇女增殖子宫内膜酸盐盐表达的影响

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Polycystic ovarian syndrome (PCOS) is a common endocrinologic disorder in women of reproductive age characterized by polycystic ovaries, oligo/anovulation, and hyperandrogenism. Not only anovulation but also endometrial dysfunction can reduce fertility in PCOS patients. Wnt pathway is responsible for endo-metrial proliferation which be strongly regulated by estradiol. To determine the effects of clomiphene citrate (CC) and letrozole, we measured the expression of some main ligands of Wnt/p-catenin signaling including Wnt7a, Wnt3, and Wnt8b in the endometrial samples taken from PCOS women on day 12 of the menses who received 100mg CC or 5 mg letrozole as well as from women without treatment. Significantly, the mean estrogen and progesterone concentration were lower and higher, respectively, in letrozole than CC. The mean endometrial thickness (ET) was significantly greater in letrozole compared to CC. Assessment of the mRNA and protein expression of Wnt7a, Wnt3, and Wnt8b showed significantly lower expression in CC than the letrozole and control groups. Collectively, letrozole provided a better molecular response in the endometrium of PCOS patients during the proliferative phase, similar to natural cycles, compared to CC. CC decreased the ligands expression of Wnt3, Wnt7a, and Wnt8b, resulting in endometrial dysfunction.
机译：多囊卵巢综合征（PCOS）是一种常见的繁殖年龄的内分泌疾病，其具有多囊卵巢，寡核苷酸/无血管和高腺癌。不仅无踝关节，还可以减少PCOS患者的生育能力。 Wnt途径负责雌二醇强烈调节的内部半导性增殖。为了确定克里芬柠檬酸盐（CC）和Letrozole的效果，我们测量了在经过PCOS女性的子宫内膜样本中的WNT / p-catenin信号传导的一些主要配体，包括Wnt7a，wnt3和Wnt8b在Mense的第12天在第12天在第12天收到100mg Cc或5mg Letrozole以及没有治疗的女性。显着地，平均雌激素和孕酮浓度分别比CC在苯并唑中较低且较高。与CC相比，Letrozole的平均子宫内膜厚度（ET）明显大。评估Wnt7a，Wnt3和Wnt8b的mRNA和蛋白表达在CC中表达明显低于Letrozole和对照组。总体上，与CC相比，Letrozole在PCOS患者的子宫内膜中提供了更好的分子响应，与CC相比，类似于天然循环。 CC降低了Wnt3，Wnt7a和Wnt8b的配体表达，导致子宫内膜功能障碍。

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