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首页> 外文期刊>Gynecologie, obstetrique & fertilit >Impact of luteal phase support by human chorionic gonadotropin (hCG) in intrauterine inseminations
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Impact of luteal phase support by human chorionic gonadotropin (hCG) in intrauterine inseminations

机译：人绒毛膜促性腺激素（HCG）在宫内衍生中的影响

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Objectives. - The objective of our study is to evaluate the impact of luteal phase support by hCG in intrauterine inseminations preceded by ovarian gonadotropin stimulation. Methods. - A retrospective study was conducted at the CHU of Nice between March 1,2016 and October 31, 2017. During this period, 300 intrauterine inseminations were included in data analysis. Ovarian stimulation was performed by gonadotropins and a GnRH antagonist was added, if needed. Following a modification of standard operative procedure in the department, patients who performed an intrauterine insemination from December 1, 2016 received luteal phase support with two injections of hCG 1500 IU, performed at three days of interval. Pregnancy and ovarian hyperstimulation syndrome were the primary and secondary study endpoints, respectively. Results. - Out of 300 inseminations included in the analysis, 144 were performed with luteal phase support and 156 without support. No statistically significant difference in pregnancy rate was observed between these two groups (19.4% of pregnancy in the luteal phase support group and 15.38% in the group without luteal phase support, P = 0.353). No ovarian hyperstimulation syndrome occurred over the course of the study. Conclusion. - Our study shows a slight improvement of pregnancy rate in the group subjected to luteal phase support by hCG after intrauterine insemination, but the benefit was not significant. A randomised prospective study based on a large cohort could help to assess the effect of luteal phase support during intrauterine inseminations.
机译：目标。 - 我们研究的目的是评估HCG在卵巢促性腺激素刺激前的宫内生精中的患力率支持的影响。方法。 - 在2016年3月1日至2017年3月31日至10月31日之间的朱楚进行了回顾性研究。在此期间，数据分析中包含300例宫内节制蛋白。如果需要，通过促性腺激素和加入GNRH拮抗剂进行卵巢刺激。在该部门的标准手术程序修改后，2016年12月1日从2016年12月1日开始宫内授权的患者接受了患有HCG 1500 IU的肺阶段支持，在三天的间隔下进行。妊娠和卵巢过度刺激综合征分别是初级和次生研究终点。结果。 - 在分析中包含的300个基因分析中，用氯化肺相载体和156次进行144个，无需支持。在这两组之间观察到妊娠率率没有统计学意义（在肺相载基团的19.4％的妊娠，其中组中15.38％，没有耐肺相载体，P = 0.353）。在研究过程中没有发生卵巢过度刺激综合症。结论。 - 我们的研究表明，在宫内生精后，HCG在患有肺相位支持的小组中对妊娠率略有提高，但益处并不重要。基于大型队列的随机前瞻性研究可以有助于评估宫内衍生过程中患力相位支持的影响。

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