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首页> 外文期刊>Gynecologie, obstetrique & fertilit >Biopathology of ovarian carcinomas early and advanced-stages: Article drafted from the French guidelines in oncology entitled 'Initial management of patients with epithelial ovarian cancer' developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa
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Biopathology of ovarian carcinomas early and advanced-stages: Article drafted from the French guidelines in oncology entitled 'Initial management of patients with epithelial ovarian cancer' developed by FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY under the aegis of CNGOF and endorsed by INCa

机译：卵巢癌的生物病理学早期和高级阶段：由Francogyn，CNGOF，SFOG，CNGOF的AEGIS的CNGOF，SFOG，CNGOF，SFOG，CNGOF的Gineco-Accagy发表的“初始管理上皮卵巢癌患者初始管理”的文章起草的文章起草的肿瘤学指南。

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Objectives. - Ovarian carcinomas represent a heterogeneous group of lesions with specific therapeutic management for each histological subtype. Thus, the correct histological diagnosis is mandatory. Material and methods. - References were searched by PubMed from January 2000 to January 2018 and original articles in French and English literature were selected. Results and conclusions. - In case of ovarian mass suspicious for cancer, a frozen section analysis may be proposed, if it could impact the surgical management. A positive histological diagnosis of ovarian carcinoma (type and grade) has to be rendered on histological (and not cytological) material before any chemotherapy with multiples and large sized biopsies. In case of needle biopsy, at least three fragments with needles > 16G are needed. Histological biopsies need to be formalin-fixed (4% formaldehyde) less than 1 h after resection and at least 6 hours fixation is mandatory for small size biopsies. Tissue transfer to pathological labs up to 48 hours under vacuum and at +4 degC (in case of large surgical specimens) may be an alternative. Gross examination should include the description of all specimens and their integrity, the site of the tumor and the dimension of all specimens and nodules. Multiples sampling is needed, including the capsule, the solid areas, at least 1 to 2 blocks per cm of tumor for mucinous lesions, the Fallopian tube in toto, at least 3 blocks on grossly normal omentum and one block on the largest omental nodule. WHO classification should be used to classify the carcinoma (type and grade), with the use of a panel of immunohistochemical markers. High-grade ovarian carcinomas (serous and endometrioid) should be tested for BRCA mutation and in case of a detectable tumor mutation, the patient should be referred to an oncogenetic consultation.
机译：目标。 - 卵巢癌代表了对每种组织学亚型的特异性治疗管理的异质病变组。因此，正确的组织学诊断是强制性的。材料与方法。 - 从2000年1月到2018年1月到2018年1月的Pubmed搜查了参考，并选择了法语和英语文学的原始文章。结果与结论。 - 如果卵巢质量可疑癌症，则可以提出冷冻截面分析，如果它可能影响手术管理。卵巢癌（类型和等级）的阳性组织学诊断必须在任何化疗的组织学（而不是细胞学）材料上，以倍增和大尺寸的活组织检查。在针活检的情况下，需要至少有三个带有针头> 16g的片段。在切除后，组织学活组织检查需要福尔马林固定（4％甲醛），并且在小尺寸活组织检查中强制固定至少6小时固定。在真空和+ 4℃下的病理实验室转移到病理实验室，并且在大型外科标本的情况下）可能是替代的。总检查应包括所有标本的描述及其完整性，肿瘤部位和所有标本和结节的尺寸。需要倍增取样，包括胶囊，固体区域，每厘米肿瘤的胶质病变，Toto中的输卵管，在常规常规环膜上至少3个嵌段，最大的题会上的一个嵌段。谁应使用分类来分类癌（类型和等级），使用免疫组织化学标记面板。应测试高级卵巢癌（浆（浆液和剂）癌（Serous和EndometroioId），用于BRCA突变，并且在可检测的肿瘤突变的情况下，患者应提及致癌咨询。

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