The immunoreactivity of TGF-beta 1 in non-alcoholic fatty liver disease

Kempinski Radoslaw; Neubauer Katarzyna; Poniewierka Elzbieta; Kaczorowski Maciej; Halon Agnieszka

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The immunoreactivity of TGF-beta 1 in non-alcoholic fatty liver disease

机译：TGF-β1在非酒精性脂肪肝病中的免疫反应性

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Introduction. Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which becomes a rapidly growing health problem in the Western countries. The development of the disease is most often connected to obesity. NAFLD is also considered as the hepatic manifestation of metabolic syndrome. Transforming growth factor beta 1 (TGF-beta 1) plays an important role in the pathogenesis of liver fibrosis, being involved in activation of hepatic stellate cells, stimulation of collagen gene transcription, and suppression of matrix metalloproteinase expression. The objective of the study was to evaluate by immunohistochemistry the expression of TGF-beta 1 in the liver tissue of NAFLD patients and correlate it with anthropometric, biochemical and routine histological parameters.

机译：介绍。非酒精性脂肪肝病（NAFLD）是一种常见的慢性肝病，成为西方国家的迅速增长的健康问题。这种疾病的发展最常与肥胖相连。 NAFLD也被认为是代谢综合征的肝脏表现。转化生长因子β1（TGF-β1）在肝纤维化的发病机制中起重要作用，参与激活肝星状细胞，胶原基因转录的刺激，以及基质金属蛋白酶的抑制。该研究的目的是通过免疫组织化学评估TGF-Beta1在NAFLD患者的肝组织中的表达，并与人类测量，生化和常规组织学参数相关。

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来源
《Folia histochemica et cytobiologica》 |2019年第2期|共10页
作者
Kempinski Radoslaw; Neubauer Katarzyna; Poniewierka Elzbieta; Kaczorowski Maciej; Halon Agnieszka;
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作者单位

Wroclaw Med Univ Dept Gastroenterol &

Hepatol Borowska 213 PL-50556 Wroclaw Poland;

Wroclaw Med Univ Dept Gastroenterol &

Hepatol Borowska 213 PL-50556 Wroclaw Poland;

Wroclaw Med Univ Dept Gastroenterol &

Hepatol Borowska 213 PL-50556 Wroclaw Poland;

Wroclaw Med Univ Dept Pathomorphol &

Oncol Cytol Wroclaw Poland;

Wroclaw Med Univ Dept Pathomorphol &

Oncol Cytol Wroclaw Poland;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
TGF-beta 1; NAFLD; liver fibrosis; liver compartments; IHC; hyaluronic acid; serum iron;

机译：TGF-β1;NAFLD;肝纤维化;肝舱;IHC;透明质酸;血清铁;

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专利

1. The immunoreactivity of TGF-beta 1 in non-alcoholic fatty liver disease [J] . Kempinski Radoslaw, Neubauer Katarzyna, Poniewierka Elzbieta, Folia histochemica et cytobiologica . 2019,第2期

机译：TGF-β1在非酒精性脂肪肝病中的免疫反应性
2. Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease Tree shrew (Tupaia belangeri chinensis), a novel non-obese animal model of non-alcoholic fatty liver disease [J] . Linqiang Zhang, Shasha Liao, Zhiguo Zhang, Biology Open . 2016,第10期

机译：树sh（Tupaia belangeri chinensis），一种非酒精性脂肪性肝病的新型非肥胖动物模型树sh（Tupaia belangeri chinensis），一种非酒精性脂肪性肝病的新型非肥胖动物模型。树sh（Tupaia belangeri chinensis）），一种非酒精性脂肪肝疾病的新型非肥胖动物模型
3. Protocol for a randomised trial testing a community fibrosis assessment service for patients with suspected non-alcoholic fatty liver disease: LOCal assessment and triage evaluation of non-alcoholic fatty liver disease (LOCATE-NAFLD) [J] . David Brain, James O’Beirne, Ingrid J. Hickman, BMC Health Services Research . 2020,第1期

机译：随机试验的议定书测试疑似非酒精脂肪肝病患者的社区纤维化评估服务：非酒精脂肪肝病的局部评估和分类评价（Locate-Nafld）
4. Development of Bioimpedance-based Measuring Systems for Diagnosis of Non-alcoholic Fatty Liver Disease [C] . Nina Gyorfi, Akos Odry, Zoltan Karadi, IEEE International Symposium on Applied Computational Intelligence and Informatics . 2021

机译：基于生物敏衡测量系统的开发，用于诊断非酒精性脂肪肝病
5. Metabolic syndrome in non-alcoholic fatty liver disease: A comparison between simple steatosis and non-alcoholic steatohepatitis [D] . Avand, Ghazal 2006

机译：非酒精性脂肪肝疾病的代谢综合征：单纯性脂肪变性和非酒精性脂肪性肝炎的比较
6. A188 COMPARING THE PERFORMANCE OF FIBROSIS-4 (FIB-4) AND NON-ALCOHOLIC FATTY LIVER DISEASE FIBROSIS SCORE (NFS) WITH FIBROSCAN SCORES IN NON-ALCOHOLIC FATTY LIVER DISEASE [O] . B D Cox, R Trasolini, C Galts, 2020

机译：A188比较FIBROSIS-4（FIB-4）和非酒精性脂肪肝疾病在非酒精性脂肪肝疾病中的纤维化评分（NFS）与纤维斑评分的比较
7. Comparing the performance of Fibrosis-4 and Non-Alcoholic Fatty Liver Disease Fibrosis Score with transient elastography scores of people with non-alcoholic fatty liver disease [O] . Ben Cox, Roberto Trasolini, Ciaran Galts, 2021

机译：比较纤维化-4和非酒精脂肪肝疾病纤维化分数的性能与非酒精脂肪肝病的瞬态弹性造影分数

The immunoreactivity of TGF-beta 1 in non-alcoholic fatty liver disease

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