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首页> 外文期刊>Expert review of cardiovascular therapy >Less than two versus greater than two hour invasive strategy in non-ST elevation myocardial infarction: a meta-analysis of randomized controlled trials
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Less than two versus greater than two hour invasive strategy in non-ST elevation myocardial infarction: a meta-analysis of randomized controlled trials

机译：非ST升高心肌梗死中不到两小时的两小时内侵入策略：随机对照试验的META分析

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Background: Optimal timing for an invasive strategy in non-ST elevation myocardial infarction (NSTEMI) is unclear. Whether clinical outcomes are improved with a less than two (LT2) compared with greater than two hour (GT2) invasive strategy remains to be determined. We performed a meta-analysis of randomized controlled trials (RCTs) comparing LT2 vs GT2 for NSTEMI. Methods: A comprehensive literature search for RCTs comparing LT2 vs. GT2 in NSTEMI patients was performed. Three eligible studies consisting of 1,075 patients (LT2: 537, GT2: 538) with NSTEMI were identified. Follow-up ranged from 1 to 12 months. Results: Time from randomization to sheath insertion ranged from 0.5-2.2 and 14.0-85.0 hours in the LT2 and GT2 groups. More percutaneous coronary interventions and fewer coronary artery bypass grafting were performed in the LT2 vs. GT2 group. There was no significant difference in all-cause mortality, myocardial infarction (Ml), and major bleeding between the two groups. LT2 was numerically, but not statistically superior to GT2 at preventing recurrent ischemia/urgent revascularization/refractory ischemia.Conclusion: Our meta-analysis found no significant difference in outcomes between less than two versus greater than two hours invasive strategy for NSTEMI. The differences observed in the mode of revascularization according to timing of catheterization deserve further study.
机译：背景：非ST升高心肌梗死（NSTemi）中的侵入性策略的最佳定时尚不清楚。与大于两小时（GT2）的侵入策略相比，临床结果是否具有少于两小时（LT2），仍有待确定仍有待确定。我们对随机对照试验（RCT）进行了META分析，比较了LT2 VT2用于NSTEMI。方法：进行了对比较NSTemi患者的LT2与GT2的RCT的综合文献搜索。三项符合条件的研究，包括1,075名患者（LT2：537，GT2：538），并进行了Nstemi。随访范围从1到12个月。结果：从随机化到鞘插入的时间范围为0.5-2.2和14.0-85.0小时，在LT2和GT2组中。在LT2与GT2基团中进行更常见的冠状动脉干预和更少的冠状动脉旁路接枝。所有原因死亡率，心肌梗塞（ml）和两组之间的重大出血都没有显着差异。 LT2在预防复发性缺血/紧急血运重建/难治性缺血时在数值上进行了数值，但没有统计学上优于GT2。结论：我们的Meta分析发现在Nstemi的少于两小时的侵入性策略中，我们的荟萃分析没有显着差异。根据导管插入率时序在血运重建模式中观察到的差异值得进一步研究。

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