Bursicon homodimers induce innate immune by activating the expression of anti-microbial peptide genes in the shrimp Neocaridina heteropoda

Li Ran; Weng Jieyang; Wang Xin; Meng Qinghao; Wang Yongyong; Sun Jinsheng

首页> 外文期刊>Fish & Shellfish Immunology >Bursicon homodimers induce innate immune by activating the expression of anti-microbial peptide genes in the shrimp Neocaridina heteropoda

【24h】

Bursicon homodimers induce innate immune by activating the expression of anti-microbial peptide genes in the shrimp Neocaridina heteropoda

机译：Bursicon同源体通过激活虾Neocaridina Suffopoda的抗微生物肽基因的表达诱导先天免疫

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Bursicon is a neurohormone belonging to the cystine knot protein family. It consists of two subunits (burs a and burs beta) and plays a pivotal role in cuticle tanning and wing expansion in insects. Recent studies show that homologous crustacean bursicon stimulates cuticle thickening and granulation of hemocytes in the crab Callinectes sapidus. Here we investigate whether bursicon homodimers function in immunoprotective defense systems of shrimp. We found that abdominal ganglion was the main neurohemal release site of bursicon in Neocaridina heteropoda. Bacterial infections induced overexpression of burs alpha (bursicon alpha) and burs beta (bursicon beta). RNAi of burs alpha, burs beta or both inhibited the expression of anti-microbial peptide (AMP) genes. Treating shrimp adults with r-bursicon (recombinant bursicon) homodimers led to up-regulation of three AMP genes. Besides, through the induced AMPs, r-bursicon homodimers enhanced the bacteriostasis of shrimp in vivo and in vitro. These findings demonstrate a novel function of bursicon in crustacean that it induces innate immune via up-regulating the expression of genes encoding AMPs.

机译：Bursicon是属于胱氨酸结蛋白家族的神经内骨。它由两个亚基（Burs A和Burs Beta）组成，并在昆虫中的角质层晒黑和翼膨胀中起着枢轴作用。最近的研究表明，同源甲壳类博尔西康刺激了螃蟹愈伤组织Sapidus中血细胞的角质层增稠和造粒。在这里，我们调查Bursicon同源过度是否在虾的免疫保护防御系统中起作用。我们发现腹部神经节是Neocaridina Suffododa的Bursicon的主要神经内释放位点。细菌感染诱导Bursα（Bursicon alpha）的过表达和Bursβ（Bursicon Beta）。 Bursα的RNAi，Burs Beta或两者均抑制抗微生物肽（AMP）基因的表达。用R-Bursicon（重组Bursicon）同源过二聚体治疗虾成年人导致了三个放大器基因的上调。此外，通过诱导的AMPS，R-Bursicon同源体增强了体内和体外虾的抑菌。这些发现表明，在甲壳类动物中的一种新功能，它可以通过Up-Chormating编码AMPS的基因表达诱导先天免疫。

著录项

来源
《Fish & Shellfish Immunology》 |2019年第2019期|共6页
作者
Li Ran; Weng Jieyang; Wang Xin; Meng Qinghao; Wang Yongyong; Sun Jinsheng;
展开▼
作者单位

Tianjin Normal Univ Tianjin Key Lab Anim &

Plant Resistance Coll Life Sci Tianjin 300387 Peoples R China;

Tianjin Normal Univ Tianjin Key Lab Anim &

Plant Resistance Coll Life Sci Tianjin 300387 Peoples R China;

Tianjin Normal Univ Tianjin Key Lab Anim &

Plant Resistance Coll Life Sci Tianjin 300387 Peoples R China;

Tianjin Normal Univ Tianjin Key Lab Anim &

Plant Resistance Coll Life Sci Tianjin 300387 Peoples R China;

Tianjin Normal Univ Tianjin Key Lab Anim &

Plant Resistance Coll Life Sci Tianjin 300387 Peoples R China;

Tianjin Normal Univ Tianjin Key Lab Anim &

Plant Resistance Coll Life Sci Tianjin 300387 Peoples R China;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类水产、渔业;
关键词
Bursicon; Homodimer; Anti-microbial peptide (AMP); Bacteriostasis; Innate immune;

机译：Bursicon;同态二聚体;抗微生物肽（AMP）;抑菌组织;天生无源;

相似文献

外文文献
中文文献
专利

1. Bursicon homodimers induce innate immune by activating the expression of anti-microbial peptide genes in the shrimp Neocaridina heteropoda [J] . Li Ran, Weng Jieyang, Wang Xin, Fish & Shellfish Immunology . 2019,第期

机译：Bursicon同源体通过激活虾Neocaridina Suffopoda的抗微生物肽基因的表达诱导先天免疫
2. Lung Delivery Studies Using siRNA Conjugated to TAT(48-60)and Penetratin Reveal Peptide Induced Reduction in Gene Expression and Induction of Innate Immunity [J] . Sterghios Athanasios Moschos, Simon Wyn Jones, Mark Michael Perry Bioconjugate Chemistry . 2007,第5期

机译：使用与TAT（48-60）和penetratin结合的siRNA的肺递送研究揭示了肽诱导的基因表达减少和先天免疫诱导
3. The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes [J] . Rafal Bartoszewski, Joseph W. Brewer, Andras Rab, The Journal of biological chemistry . 2011,第48期

机译：展开的蛋白质反应（UPR） - 活化的转录因子X型盒结合蛋白1（XBP1）诱导靶向人抗原肽转运蛋白1（Tap1）mRNA的MicroRNA-346表达，并治理免疫调节基因
4. A Temporal Analysis of the Bovine Innate Immune ResponseA Temporal Analysis of the Bovine Innate Immune Response: The Identification and Characterization of Host Defense Peptides by Mass Spectrometry [C] . Jeffrey A. DeGrasse, Jamie L. Boehmer, Kevin J. Shefcheck, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：牛先天免疫应答牛先天性免疫应答的时间分析：质谱法鉴定和表征宿主防毒肽
5. The Role of Innate Immunity and Interferon-Inducible Genes in the Regulation of Host Defense in Re-Emerging West Nile Virus and Influenza. [D] . Sidahmed, Abubaker M. E. 2014

机译：先天免疫和干扰素诱导型基因在重新出现西尼罗河病毒和流感的宿主防御中的作用。
6. Insect Neuropeptide Bursicon Homodimers Induce Innate Immune and Stress Genes during Molting by Activating the NF-κB Transcription Factor Relish [O] . Shiheng An, Shengzhang Dong, Qian Wang, 2009

机译：昆虫神经肽Bursicon同态基因通过激活NF-κB转录因子的作用诱导蜕皮过程中的天然免疫和应激基因
7. Insect Neuropeptide Bursicon Homodimers Induce Innate Immune and Stress Genes during Molting by Activating the NF-κB Transcription Factor Relish [O] . An, Shiheng, Dong, Shengzhang, Wang, Qian, 2012

机译：昆虫神经肽Bursicon同态基因通过激活NF-κB转录因子的作用诱导蜕皮过程中的天然免疫和应激基因

Bursicon homodimers induce innate immune by activating the expression of anti-microbial peptide genes in the shrimp Neocaridina heteropoda

摘要

著录项

相似文献

相关主题

期刊订阅