Perforin-expressing IGT plus B cell with cytotoxic activity, a novel player in the innate immune response of teleost fish

Shibasaki Yasuhiro; Takizawa Fumio; Ding Yang; Boudinot Pierre; Sunyer Oriol

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Perforin-expressing IGT plus B cell with cytotoxic activity, a novel player in the innate immune response of teleost fish

机译：具有细胞毒性活性的穿孔素 - 表达Igt Pruct B细胞，这是一个新的球员在Textost鱼的先天免疫反应中

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来源
《Fish & Shellfish Immunology》 |2019年第2019期|共1页
作者
Shibasaki Yasuhiro; Takizawa Fumio; Ding Yang; Boudinot Pierre; Sunyer Oriol;
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作者单位

Univ Penn Sch Vet Med Dept Pathobiol Philadelphia PA 19104 USA;

Fukui Prefectural Univ Fac Marine Sci &

Technol Fukui Japan;

Univ Penn Sch Vet Med Dept Pathobiol Philadelphia PA 19104 USA;

Univ Paris Saclay Virol &

Immunol Mol INRA Jouy En Josas France;

Univ Penn Sch Vet Med Dept Pathobiol Philadelphia PA 19104 USA;

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原文格式 PDF
正文语种 eng
中图分类水产、渔业;
关键词
IgT plus B cell; Perforin; Innate immunity; cytotoxicity;

机译：IGT Plus B细胞;穿孔素;先天免疫;细胞毒性;

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专利

1. Perforin-expressing IGT plus B cell with cytotoxic activity, a novel player in the innate immune response of teleost fish [J] . Shibasaki Yasuhiro, Takizawa Fumio, Ding Yang, Fish & Shellfish Immunology . 2019,第期

机译：具有细胞毒性活性的穿孔素 - 表达Igt Pruct B细胞，这是一个新的球员在Textost鱼的先天免疫反应中
2. Streptococcus iniae inhibition of apoptosis of nonspecific cytotoxic cells: a mechanism of activation of innate immunity in teleosts [J] . Andrew B. Allison, Avi Eldar, Donald L. Evans, Diseases of Aquatic Organisms . 2001,第1期

机译：链球菌抑制非特异性细胞毒性细胞凋亡：硬骨鱼先天免疫活化的机制
3. The circular RNA circBCL2L1 regulates innate immune responses via microRNA-mediated downregulation of TRAF6 in teleost fish [J] . Weiwei Zheng, Lingping Sun, Liyuan Yang, The Journal of biological chemistry . 2021,第4期

机译：圆形RNA QIMBCL2L1通过MicroRNA介导的TRAF6在TextoST鱼中调节先天免疫应答
4. Immunisation with a rHsp70-GFP fusion protein elicits cellular and humoral immune responses but no cytotoxic T cell reactivity in cattle [C] . Langelaar M, Hoek A, van Eden-W, International Colloquium on Paratuberculosis . 2007

机译：用RHSP70-GFP融合蛋白免疫引发细胞和体液免疫应答，但在牛中没有细胞毒性T细胞反应性
5. Cytotoxic activity of the bacterial fish pathogen Flavobacterium columnare on fish cells [D] . Peselis, Alla Alexandra 2011

机译：鱼细菌性病原菌黄杆菌对鱼细胞的细胞毒活性
6. Inducible MicroRNA-3570 Feedback Inhibits the RIG-I-Dependent Innate Immune Response to Rhabdovirus in Teleost Fish by Targeting MAVS/IPS-1 [O] . Tianjun Xu, Qing Chu, Junxia Cui, 2018

机译：可诱导的MicroRNA-3570反馈通过靶向MAVS / IPS-1来抑制对硬骨鱼中弹状病毒的RIG-I依赖性先天免疫反应。
7. Six practical diets were formulated to contain 2.6 (the basal diet), 48.9, 95.5, 189.83, 382.4, 779.53 mg/kg vitamin C diet. After 8 weeks of feeding, growth performance, antioxidant status, and innate immunity of juvenile pufferfish were analyzed. Results showed that specific growth rate and protein efficiency ratio in fish fed diets supplemented with vitamin C were significantly higher than in fish fed the control diet. Dietary vitamin C significantly up-regulated the expression levels of growth hormone receptors and Insulin-like growth factor. Blood cell numbers and respiratory burst activity were enhanced in fish fed vitamin C diet. Serum alkaline phosphatase, glutamic-pyruvic transaminase, and glutamic-oxaloacetic transaminase activity were significantly influenced by the dietary vitamin C levels. Fish fed diets supplemented with vitamin C showed increased hepatic superoxide dismutase, glutathione peroxidase, and catalase activity, but decreased malondialdehyde activity. In addition, we found that dietary vitamin C can significantly up-regulate the expression levels of immune-related genes (HSP70, HSP90, BAFF, TNF-α and IL-6) in liver. These results indicate that dietary vitamin C can significantly influence growth performance, antioxidant status, and innate immunity of pufferfish. [O] . Cheng C-H, Liang H-Y., Guo Z-X., 2017

机译：配制了六种实用饮食，分别含有2.6（基础饮食），48.9、95.5、189.83、382.4、779.53 mg / kg维生素C饮食。喂食8周后，分析了幼崽河豚的生长性能，抗氧化剂状态和先天免疫力。结果表明，补充维生素C的鱼饲料的比生长速率和蛋白质效率比显着高于对照组的鱼。饮食中的维生素C显着上调了生长激素受体和胰岛素样生长因子的表达水平。喂鱼的维生素C饮食可提高血细胞数量和呼吸爆发活性。饮食中的维生素C水平显着影响血清碱性磷酸酶，谷氨酸-丙酮酸转氨酶和谷氨酸-草酰乙酸转氨酶的活性。补充维生素C的鱼饲料日粮中肝超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶活性增加，但丙二醛活性降低。此外，我们发现饮食中的维生素C可以显着上调肝脏中免疫相关基因（HSP70，HSP90，BAFF，TNF-α和IL-6）的表达水平。这些结果表明，饮食中的维生素C可以显着影响河豚的生长性能，抗氧化状态和先天免疫力。

Perforin-expressing IGT plus B cell with cytotoxic activity, a novel player in the innate immune response of teleost fish

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