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首页> 外文期刊>Fish Physiology and Biochemistry >High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish
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High-carbohydrate diet promotes the adaptation to acute hypoxia in zebrafish

机译：高碳水化合物饮食促进斑马鱼急性缺氧的适应

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Oxygen deprivation (hypoxia) is a common challenge in water environment, which causes lack of energy and oxidative damage in organisms. Many studies have indicated a number of physiological and metabolic changes under hypoxia, but the effects of dietary nutrients on hypoxia tolerance have not been well evaluated. In the present 7-week feeding trial, we fed zebrafish with low-protein diet (LP), high-protein diet (HP), low-fat diet (LF), high-fat diet (HF), low-carbohydrate diet (LC), and high-carbohydrate diet (HC), respectively. Afterward, the resistance to acute hypoxia challenge, growth, body composition, activities of metabolic enzymes, and expressions of energy homeostasis-related genes and six hif alpha s genes were measured. The results indicated that only the HC diet could significantly improve the resistance to hypoxia challenge. Moreover, the HC diet feeding caused higher glycogen deposition in the liver and muscle, and these glycogens were significantly reduced after 6-h acute hypoxia challenge. Meanwhile, the lactate content in the liver and blood was increased in the HC groups. At hypoxia status, the relative mRNA expressions of the genes related to glycolysis, ATP production, insulin signaling pathway, and hif-3a (hif1al) were all significantly increased in the muscle of the HC diet-fed fish. This study revealed that high-carbohydrate diet could improve the resistance to hypoxia by activating glycolysis and hif/insulin signaling pathway in zebrafish, mainly in the muscle, to efficiently supply energy. Therefore, our results highlight the importance of dietary carbohydrate in resisting hypoxia in fish.
机译：缺氧（缺氧）是水环境中的共同挑战，这导致生物体中缺乏能量和氧化损伤。许多研究表明了缺氧下的一些生理和代谢变化，但膳食营养物质对缺氧耐受性的影响尚未得到很好的评估。在目前的7周喂养试验中，我们用低蛋白质饮食（LP），高蛋白质饮食（HP），低脂饮食（LF），高脂饮食（HF），低碳水化合物饮食（ LC）和高碳水化合物饮食（HC）。之后，测量抗急性缺氧挑战，生长，身体组成，代谢酶的活性，以及​​能量稳态相关基因的表达和六个HIFαS基因。结果表明，只有HC饮食可以显着提高对缺氧挑战的抵抗力。此外，HC饮食喂养在肝脏和肌肉中引起了更高的糖原沉积，并且在6-H急性缺氧攻击后，这些糖蛋白显着降低。同时，HC组中肝脏和血液中的乳酸含量增加。在缺氧状态下，与糖酵解，ATP生产，胰岛素信号传导途径和HIF-3A（HIF1AL）相关的基因的相对mRNA表达在HC饮食喂食鱼的肌肉中大大增加。该研究表明，通过在斑马鱼的晶圆下激活糖酵解和HIF /胰岛素信号传导途径，高碳水化合物饮食可以通过激活糖粉和HIF /胰岛素信号传导途径来改善缺氧，主要在肌肉中，以有效地提供能量。因此，我们的结果突出了膳食碳水化合物在抗鱼中抗缺氧的重要性。

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