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首页> 外文期刊>Fish Physiology and Biochemistry >Antioxidant metabolism of zebrafish after sub-lethal exposure to graphene oxide and recovery
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Antioxidant metabolism of zebrafish after sub-lethal exposure to graphene oxide and recovery

机译：亚麻致死暴露于石墨烯氧化物和回收后斑马鱼的抗氧化剂代谢

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摘要

Graphene oxide (GO) is a carbon nanomaterial with specific properties, which allow its use in several areas. Some studies have characterized the effects of GO on aquatic organisms, but the ability of recovery after exposure remains largely unknown. In this study, we evaluated the effects of GO on the antioxidant metabolism of zebrafish after 48 h of sub-lethal exposure, and the fish recovery after 168 h in nanoparticle-free water. After the sub-lethal exposure, superoxide dismutase (SOD) activity was significantly increased in 20 mg L-1, as well as catalase (CAT) activity in 2, 10, and 20 mg L-1, and the lipid peroxidation (LPO) had an increase in 2 mg L-1. On other hand, the glutathione peroxidase (GPx) activity was inhibited at 20 mg L-1. After 168 h of recovery in clean water, the SOD activity remained significantly increased in 20 mg L-1; the CAT activity was unchanged in all tested concentrations; the GPx activity was inhibited in 2, 10, and 20 mg L-1; and the LPO significantly decreased in 2 mg L-1. Our study suggests that GO exposure disrupts the antioxidant metabolism of adult zebrafish. Even after 168 h of recovery in clean water, homeostasis was not completely restored, although organisms developed mechanisms of recovery, and toxic effects were more subtle. Our results are pivotal to better understanding the physiological mechanisms involved in the detoxification process after GO exposure, and for strategies of protection on fish species.
机译：石墨烯氧化物（GO）是一种具有特定性质的碳纳米材料，其允许其在几个区域中使用。一些研究表征了去对水生生物的影响，但暴露后的恢复能力仍然很近。在这项研究中，我们评估了在亚致死暴露48小时后对斑马鱼抗氧化代谢的影响，并在纳米粒子水中的168小时后的鱼恢复。在亚致死暴露后，超氧化物歧化酶（SOD）活性在20mg L-1中显着增加，以及2,10和20mg L-1中的过氧化氢酶（猫）活性，以及​​脂质过氧化（LPO）增加了2 mg l-1。另一方面，在20mg L-1抑制谷胱甘肽过氧化物酶（GPX）活性。在清水中恢复168小时后，20mg L-1的SOD活性仍然显着增加;在所有测试浓度下，猫活动保持不变;在2,10和20mg L-1中抑制了GPX活性;在2mg L-1中，LPO显着降低。我们的研究表明，去暴露会破坏成人斑马鱼的抗氧化代谢。即使在清洁水中恢复168小时后，稳态也没有完全恢复，尽管有机体发展恢复机制，毒性效应更加微妙。我们的结果是为了更好地理解在去接触后涉及排毒过程中涉及的生理机制，以及用于鱼种的保护策略。

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  • 来源
    《Fish Physiology and Biochemistry》 |2019年第4期|共9页
  • 作者

    Souza Jaqueline P.; Mansano Adrislaine S.; Venturini Francine P.; Santos Fabricio; Zucolotto Valtencir;

  • 作者单位

    Univ Sao Paulo Nanomed &

    Nanotoxicol Grp Phys Inst Sao Carlos IFSC Ave Trabalhador Sao Carlense 400 BR-13560970 Sao Carlos SP Brazil;

    Univ Sao Paulo Nanomed &

    Nanotoxicol Grp Phys Inst Sao Carlos IFSC Ave Trabalhador Sao Carlense 400 BR-13560970 Sao Carlos SP Brazil;

    Univ Sao Paulo Nanomed &

    Nanotoxicol Grp Phys Inst Sao Carlos IFSC Ave Trabalhador Sao Carlense 400 BR-13560970 Sao Carlos SP Brazil;

    Univ Sao Paulo Nanomed &

    Nanotoxicol Grp Phys Inst Sao Carlos IFSC Ave Trabalhador Sao Carlense 400 BR-13560970 Sao Carlos SP Brazil;

    Univ Sao Paulo Nanomed &

    Nanotoxicol Grp Phys Inst Sao Carlos IFSC Ave Trabalhador Sao Carlense 400 BR-13560970 Sao Carlos SP Brazil;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 水产、渔业;
  • 关键词

    Fish; Nanoparticles; Enzyme activity; Freshwater; Detoxification;

    机译：鱼;纳米颗粒;酶活性;淡水;排毒;

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