Three forms of cocaine- and amphetamine-regulated transcript may be involved in food intake regulation in gibel carp (Carassius auratus gibelio)

Zhou Chaowei; Lei Luo; Deng Xingxing; Yuan Dengyue; Zhu Chengke; Ye Hua; Luo Hui; Zhang Chi; Zhou Jianshe; Yang Minmin; Wang Jian; Zeng Benhe; Li Baohai; Zheng Zonglin

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Three forms of cocaine- and amphetamine-regulated transcript may be involved in food intake regulation in gibel carp (Carassius auratus gibelio)

机译：可卡因和安非胺调节的转录物的三种形式可参与Gibel Carp（Carassius auratus Gibelio）的食物摄入调节

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In fish, as in mammals, several studies have demonstrated that the cocaine- and amphetamine-regulated transcript (CART) plays an important role in feeding. However, thus far, the function of CART in gibel carp (Carassius auratus gibelio) feeding regulation has not been reported. In our study, we first identified three forms of CART peptide precursors from gibel carp brain and named these CART-1, CART-2, and CART-3. The full-length cDNA sequences of CART-1, CART-2, and CART-3 were 616bp, 705bp, and 760bp, respectively, encoding peptides of 118, 120, and 104 amino acid residues. We detected mRNA expression of CART-1, CART-2, and CART-3 in a wide range of peripheral and central tissues, with the highest expression detected in the brain. After a meal, mRNA expression of CART-1, CART-2, and CART-3 was significantly elevated, suggesting that CART-1, CART-2, and CART-3 may act as postprandial satiety signals. Moreover, mRNA expression of all three CART-1, CART-2, and CART-3 was significantly reduced during fasting and significantly elevated with refeeding. Our findings indicate that CART-1, CART-2, and CART-3 might function as a satiety factor in the gibel carp.

机译：在鱼类中，如在哺乳动物中，几项研究表明，可卡因和安非他明调节的转录物（推车）在饲养中起重要作用。然而，到目前为止，尚未报道刺痛鲤鱼（Carassius auratus Gibelio）喂养调节的推车的功能。在我们的研究中，我们首先将三种形式的来自吉布尔鲤鱼大脑的购物车肽前体，并命名为这些购物车-1，购物车-2和购物车3。 Cart-1，Cart-2和Cart-3的全长cDNA序列分别为616bp，705bp和760bp，编码118,120和104个氨基酸残基的肽。我们在各种外周和中枢组织中检测到Cart-1，Cart-2和Cart-3的mRNA表达，并且在大脑中检测到最高表达。在膳食之后，Cart-1，Cart-2和Cart-3的mRNA表达显着升高，表明购物车-1，卡特卡和购物车3可以充当餐后饱足信号。此外，在禁食期间，所有三个购物车-1，CART-2和CART-3的mRNA表达显着降低，并在精选方面显着升高。我们的研究结果表明，购物车-1，Cart-2和Cart-3可以作为吉布尔鲤鱼中的饱腹感因素。

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来源
《Fish Physiology and Biochemistry》 |2019年第3期|共13页
作者
Zhou Chaowei; Lei Luo; Deng Xingxing; Yuan Dengyue; Zhu Chengke; Ye Hua; Luo Hui; Zhang Chi; Zhou Jianshe; Yang Minmin; Wang Jian; Zeng Benhe; Li Baohai; Zheng Zonglin;
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作者单位

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Neijiang Normal Univ Coll Life Sci Dept Aquaculture Neijiang 641000 Sichuan Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Tibet Acad Agr &

Anim Husb Sci Lhasa 850002 Tibet Peoples R China;

Tibet Acad Agr &

Anim Husb Sci Lhasa 850002 Tibet Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

Tibet Acad Agr &

Anim Husb Sci Lhasa 850002 Tibet Peoples R China;

Tibet Acad Agr &

Anim Husb Sci Lhasa 850002 Tibet Peoples R China;

Southwest Univ Coll Anim Sci Dept Aquaculture Chongqing 402460 Peoples R China;

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正文语种 eng
中图分类水产、渔业;
关键词
Cocaine- and amphetamine-regulated transcript; Cloning; Fasting; Feeding; Gibel carp;

机译：可卡因和安非他明的转录物;克隆;禁食;喂养;吉布尔鲤鱼;

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专利

1. Three forms of cocaine- and amphetamine-regulated transcript may be involved in food intake regulation in gibel carp (Carassius auratus gibelio) [J] . Zhou Chaowei, Lei Luo, Deng Xingxing, Fish Physiology and Biochemistry . 2019,第3期

机译：可卡因和安非胺调节的转录物的三种形式可参与Gibel Carp（Carassius auratus Gibelio）的食物摄入调节
2. Function characterization and expression regulation of two different-sized 3 ' untranslated region-containing interferon genes from clone F of gibel carp Carassius auratus gibelio [J] . Molecular Immunology . 2020,第期

机译：来自Gibel Carassius Auratus Gibelio的克隆F的两种不同尺寸的3'未旋转区域干扰素基因的功能表征及表达调节
3. Characterization of bmp15 and its regulation by human chorionic gonadotropin in the follicle of gibel carp (Carassius auratus gibelio) [J] . Chen A.-Q., Liu Z.-W., Yang Z.-G., Comparative biochemistry and physiology, Part B. Biochemistry & molecular biology . 2012,第1期

机译：长鳍鲤（Carassius auratus gibelio）卵泡中bmp15的特性及其受绒毛膜促性腺激素调节
4. Effect of Blue-green Algae Meal on Growth and Accumulation of Microcystins in gibel carp(Carassius auratus gibelio) [C] . Symposium of world's Chinese scientists on nutrition and feeding of finfish and shellfish . 2005

机译：青绿藻类膳食对吉布尔鲤鱼微囊藻（Carassius auratus Gibelio）生长和积累的影响
5. Cocaine- and amphetamine-regulated transcript peptide attenuates baroreflex in the rat. [D] . Scruggs, Phouangmala C. 2003

机译：可卡因和苯丙胺调节的转录肽减弱了大鼠的压力反射。
6. Synergistic effect of CART (cocaine- and amphetamine-regulated transcript) peptide and cholecystokinin on food intake regulation in lean mice [O] . Lenka Maletínská, Jana Maixnerová, Resha Matyšková, 2008

机译：CART（可卡因和苯丙胺调节的转录物）肽和胆囊收缩素对瘦小鼠食物摄入调节的协同作用
7. Myxobolus oralis sp. n. (Myxosporea: Bivalvulida) infecting the palate in the mouth of gibel carp Carassius auratus gibelio (Cypriniformes: Cyprinidae) [O] . Yang Liu, Christopher M. Whipps, Pin Nie, 2014

机译：myxobolus oralis sp。 ñ。（myxosporea：BivalVulida）感染吉布尔鲤鱼鲫鱼口腭吉布里奥（Cypriniformes：cyprinidae）

Three forms of cocaine- and amphetamine-regulated transcript may be involved in food intake regulation in gibel carp (Carassius auratus gibelio)

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