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首页> 外文期刊>Fish Physiology and Biochemistry >Protection of teprenone against hypoxia and reoxygenation stress in stomach and intestine of Lateolabrax maculatus
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Protection of teprenone against hypoxia and reoxygenation stress in stomach and intestine of Lateolabrax maculatus

机译：保护胸酮对胃癌和肠胃肠道的缺氧和雷诺应激的保护

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摘要

Teprenone (geranylgeranylacetone) is one kind of safe and effective agent in gastrointestinal mucosa, which have been widely used in human and veterinary, but rarely used in aquaculture animals. In this study, Lateolabrax maculatus, an important economic fish species in southern China, was taken as the object of study to investigate the protective effect of teprenone on intestinal stress. The present study was designed to investigate the potential mechanism underlying the protection offered by teprenone to protect the gastrointestinal tract against hypoxia and reoxygenation injury of L. maculatus. (a) For oxidative stress parameters, SOD, CAT, and T-AOC in control group were higher than those in teprenone group. MDA content was significantly higher than that in teprenone group at N and 12h time points in intestine (P < 0.05), and at 12, 24, and 48 h time points in stomach. (b) For immune-associated proteins, LZM activity in the control group was lower than that in the teprenone group, and the difference between the two groups in stomach and intestine was significant at 12.48 h and 6.48 h time points, respectively (P < 0.05). Compared with time point N, the content of HSP70 in the control group increased at 0 h in intestine. At 0-48 h, intestine HSP70 content in the control group showed a gradually decreasing trend, which was higher than that in the teprenone group. (c) For apoptosis-related factors, the activity of Cyt-C, caspase9, and caspase3 increased first and then decreased in both groups. The content of Cyt-C in the control group was significantly higher than that in the teprenone group at N-3.6 h, and 3.48 h time points in stomach and intestine, respectively (P<0.05). The activity of caspase9 and caspase3 was higher than that in the teprenone group at N-48 h. Results indicated that acute hypoxia and reoxygenation cause the expression levels of oxidative stress and apoptosis-related factors in the stomach and intestine increased first and then decreased within 0-48 h. Acute hypoxia and reoxygenation also that causes the level of nonspecific immunity decreased first and then increased. A total of 400-mg/kg treatment of teprenone can protect stomach and intestinal tissues to a certain extent. It can effectively protect oxidative stress and apoptosis within 0-48 h after acute hypoxia and reoxygenation and enhance non-specific immunity.
机译：Tepronone（Geranylgeranylacetone）是胃肠粘膜中一种安全有效的药剂，其已广泛用于人和兽医，但很少用于水产养殖动物。在本研究中，中国南部重要的经济鱼类梯洛克拉克斯马鲁拉斯被视为研究史丙酮对肠胁迫的保护作用。本研究旨在调查特普酮提供的保护潜在机制，以保护胃肠道免受L. Maculatus的缺氧和雷诺损伤。 （a）对对照组的氧化应激参数，SOD，猫和T-Aoc高于Tepronone基团的SOD，猫和T-Aoc。 MDA含量明显高于N和12H的肠道组（P <0.05），12,24和48小时的时间点。 （b）对于免疫相关蛋白，对照组中的LZM活性低于Tepronone基团的LZM活性，分别在12.48小时和6.48小时的胃和肠中的两组之间的差异分别是显着的（P < 0.05）。与时间点N相比，对照组中HSP70的含量在肠中升高0小时。在0-48小时，对照组的肠Hsp70含量显示逐渐降低趋势，其趋势高于Tepronone组。 （c）对于相关的凋亡相关因素，Cyt-C，Caspase9和Caspase3的活性首先增加，然后在两组中降低。对照组的CYT-C含量显着高于N-3.6 H的己酮基团，分别为3.48小时，分别为3.48小时（P <0.05）。 Caspase9和Caspase3的活性高于N-48h的己酮基团的活性。结果表明，急性缺氧和重新氧化引起胃癌和肠凋亡相关因子的表达水平首先增加，然后在0-48小时内降低。急性缺氧和再氧化也使得不特异性免疫水平首先下降，然后增加。总共400毫克/千克治疗德前酮可以在一定程度上保护胃和肠组织。它可以有效地保护急性缺氧和雷诺酸盐后0-48小时内的氧化应激和细胞凋亡，增强非特异性免疫。

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  • 来源
    《Fish Physiology and Biochemistry》 |2020年第2期|共10页
  • 作者

    Sun YongXu; Dong HongBiao; Zhan AiJun; Wang WenHao; Duan YaFei; Xie Mujiao; Liu QingSong; Li Hua; Zhang JiaSong;

  • 作者单位

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

    Shenzhen Acad Inspection Quarantine Shenzhen Peoples R China;

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

    S China Sea Fisheries Res Inst Chinese Acad Fishery Sciences Key Lab S China Sea Fishery Resources Exploitat Utilization Minist Agr Rural Affairs Guangzhou Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 水产、渔业;
  • 关键词

    Teprenone; Hypoxia; Reoxygenation; Injury; Lateolabrax maculatus;

    机译：特丙酮;缺氧;重新氧化;伤害;鼠罗拉克斯maculatus;

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