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首页> 外文期刊>Frontiers in neuroendocrinology >Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?
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Individual differences in glucocorticoid regulation: Does it relate to disease risk and resilience?

机译:糖皮质激素调节的个体差异:它是否涉及疾病风险和韧性?

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Glucocorticoid (GC) signaling varies among individuals, and this variation may relate to individual differences in health outcomes. To determine if and which aspects of signaling (basal, circadian, integrative, or reactivity) are associated with specific health outcomes, we reviewed recent studies that relate GCs to health outcomes. We identified papers through PubMed and reviewed 100 original research articles related to mental health, cardiovascular health, cancer, diabetes, obesity, pulmonary health, sleep, and fitness. Many studies reported elevated GC secretion associated with worse health, but this was only particularly true for integrative GC measures. On the other hand, accentuated cortisol awakening response and a steeper circadian rhythm were both associated with positive health outcomes. Overall, relationships between GC secretion and health outcomes were relatively weak. This systematic review of relationships between GC metrics and health outcomes highlights the importance of careful consideration when selecting methods to measure GC regulation in health research.
机译:糖皮质激素(GC)信号传导在个体之间变化,这种变异可能与健康结果的个体差异有关。为了确定信号传导(基础,昼夜节律,一体化或反应性)与特定的健康结果相关的,我们审查了最近的研究,这些研究将GCS与健康结果相关。我们通过PubMed识别论文并审查了与心理健康,心血管健康,癌症,糖尿病,肥胖,肺部健康,睡眠和健身有关的100个原始研究文章。许多研究报告了与更严重的健康状况相关的GC分泌率升高,但这对于综合性GC措施仅尤为真实。另一方面,突出的皮质醇唤醒响应和陡峭的昼夜节律均与积极的健康结果相关。总体而言,GC分泌与健康结果之间的关系相对较弱。这种对GC指标与健康结果之间的关系的系统审查突出了仔细考虑在选择衡量卫生研究中的GC规则时仔细考虑的重要性。

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