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首页> 外文期刊>Frontiers in neuroendocrinology >Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders
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Individual differences in inflammatory and oxidative mechanisms of stress-related mood disorders

机译：炎症和氧化机制对压力相关情绪障碍的个体差异

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摘要

Emotional stress leads to the development of peripheral disorders and is recognized as a modifiable risk factor for psychiatric disorders, particularly depression and anxiety. However, not all individuals develop the negative consequences of emotional stress due to different stress coping strategies and resilience to stressful stimuli. In this review, we discuss individual differences in coping styles and the potential mechanisms that contribute to individual vulnerability to stress, such as parameters of the immune system and oxidative state. Initial differences in inflammatory and oxidative processes determine resistance to stress and stress-related disorders via the alteration of neurotransmitter content in the brain and biological fluids. Differences in coping styles may serve as possible predictors of resistance to stress and stress-related disorders, even before stressful conditions. The investigation of natural variabilities in stress resilience may allow the development of new methods for preventive medicine and the personalized treatment of stress-related conditions.
机译：情绪压力导致外周疾病的发展，被认为是精神病疾病，特别是抑郁和焦虑的可改性危险因素。然而，由于不同的压力应对策略和适应压力刺激，所有人并非所有人都会产生情绪压力的负面后果。在本文中，我们讨论了应对风格的个体差异和有助于对压力的个体脆弱性有助于的潜在机制，例如免疫系统和氧化状态的参数。炎症和氧化过程的初始差异通过在大脑和生物流体中的神经递质含量改变神经递质含量的改变来确定对应力和相关疾病的抵抗力。即使在压力条件之前，应对风格的差异也可以作为对应力和相关疾病的抗性的可能预测因子。对压力弹性的天然变形性的调查可能允许开发用于预防医学的新方法以及与压力相关条件的个性化治疗。

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