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首页> 外文期刊>Frontiers in neuroendocrinology >In search of optimal resilience ratios: Differential influences of neurobehavioral factors contributing to stress-resilience spectra
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In search of optimal resilience ratios: Differential influences of neurobehavioral factors contributing to stress-resilience spectra

机译：寻求最佳弹性比率：神经兽性因素对应力 - 弹性谱的差异影响

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The ability to adapt to stressful circumstances, known as emotional resilience, is a key factor in the maintenance of mental health. Several individual biomarkers of the stress response (e.g., corticosterone) that influence an animal's position along the continuum that ranges from adaptive allostasis to maladaptive allostatic load have been identified. Extending beyond specific biomarkers of stress responses, however, it is also important to consider stress-related responses relative to other relevant responses for a thorough understanding of the underpinnings of adaptive allostasis. In this review, behavioral, neurobiological, developmental and genomic variables are considered in the context of emotional resilience [e.g., explore/exploit behavioral tendencies; DHEA/CORT ratios and relative proportions of protein-coding/nonprotein-coding (transposable) genomic elements]. As complex and multifaceted relationships between pertinent allostasis biomediators are identified, translational applications for optimal resilience are more likely to emerge as effective therapeutic strategies.
机译：适应压力情况（称为情绪恢复力）的能力是维持心理健康的关键因素。已经鉴定了影响动物沿着适应性血管阻滞的连续局部对适应血管载荷的连续局部的应激反应（例如皮质酮）的几个生物标志物。然而，超出了应力反应的特定生物标志物，同样重要的是考虑相对于其他相关响应的应力相关的反应，以彻底了解适应性血管外的基础。在这种审查中，在情绪恢复力的背景下考虑行为，神经生物学，发育和基因组变量[例如，探索/利用行为倾向; DHEA / CORT比例和相对比例的蛋白质编码/非蛋白编码（可转移）基因组元素]。由于确定了相关血栓生物实体师之间的复杂和多方面的关系，更有可能成为有效的治疗策略的最佳弹性的翻译应用。

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