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首页> 外文期刊>Frontiers in neuroendocrinology >Estrogens and SERMS as adjunctive treatments for schizophrenia
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Estrogens and SERMS as adjunctive treatments for schizophrenia

机译：雌激素和SERMS作为精神分裂症的辅助治疗方法

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More than thirty years have passed since sex and gender differences were noted in the age of onset, course and outcomes for schizophrenia. The 'estrogen hypothesis" was coined in the 1990's to describe neuroprotective effects of estrogen. Intervention studies in schizophrenia patients with estradiol and selective estrogen receptor modulators (SERMs) are promising but psychiatrists and other health practitioners do not generally take up this useful adjunctive treatment for their female patients with schizophrenia. The reasons for this are manifold, but overall a cultural shift in the practice of psychiatry is needed to recognise the specific needs of women with schizophrenia and tailor treatments, such as hormone adjuncts to improve the outcomes for this significant population. The two main aims of this article are to review the evidence and theory of estrogen treatments in schizophrenia and to recommend translation of adjunctive estrogen treatment into clinical practice for women with schizophrenia.
机译：自从性别和性别差异在精神分裂症的阶段，课程和结果中指出的性别和性别差异以来已经过去三十多年。 “雌激素假设”是在1990年代中的，描述了雌激素的神经保护作用。精神分裂症患者的苯并二醇和选择性雌激素受体调节剂（SERMS）的干预研究是有前途的，但精神病学家和其他卫生从业者通常不会占用这种有用的辅助治疗他们的女性患有精神分裂症的患者。这种原因是歧管，但整体所需的文化转变需要精神病学的实践，以认识到患有精神分裂症和定制治疗的妇女的特定需求，例如激素辅助，以改善这一重要人群的结果。本文的两个主要目的是审查精神分裂症治疗雌激素治疗的证据和理论，并推荐辅助雌激素治疗的临床实践中患有精神分裂症的临床实践。

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